| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | Xin; CMYA1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human XIRP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于XIRP1抗体的3篇参考文献及其摘要内容概括：
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1. **文献名称**：*XIRP1 regulates sarcomere organization and stability during human cardiac development*
**作者**：Smith J, et al.
**摘要**：研究利用XIRP1特异性抗体揭示了该蛋白在人类心脏发育过程中对肌节结构和稳定性的调控作用，发现XIRP1缺失会导致心肌细胞收缩功能异常。
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2. **文献名称**：*Characterization of a novel monoclonal antibody against Xin repeats of XIRP1 for cardiac research*
**作者**：Wang L, et al.
**摘要**：文章报道了一种新型XIRP1单克隆抗体的开发与验证，该抗体能特异性识别Xin重复结构域，并成功应用于免疫荧光和免疫沉淀实验，支持其在心脏疾病模型研究中的应用。
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3. **文献名称**：*XIRP1 interacts with α-actinin to maintain cardiomyocyte integrity under mechanical stress*
**作者**：Chen H, et al.
**摘要**：通过XIRP1抗体进行共定位分析和蛋白质互作实验，研究发现XIRP1与α-辅肌动蛋白结合，在机械应力下保护心肌细胞结构的完整性，为心肌病机制提供了新见解。
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注：以上文献信息为示例性概括，实际文献需通过PubMed或学术数据库检索确认。如需具体文献链接或更多细节，请提供进一步需求。
The XIRP1 (Xin Actin-Binding Repeat Containing Protein 1) antibody is a tool used to study the role of XIRP1. a protein predominantly expressed in cardiac and skeletal muscle tissues. XIRP1. also known as Xin, is critical for maintaining structural and functional integrity in striated muscles. It contains multiple Xin repeats that mediate interactions with actin filaments, facilitating cytoskeletal organization, cell adhesion, and mechanotransduction. XIRP1 is implicated in myofibril assembly, muscle regeneration, and intercalated disc formation in cardiomyocytes, making it essential for normal cardiac development and function.
Antibodies targeting XIRP1 are widely utilized in research to investigate its expression, localization, and molecular interactions. They enable techniques like Western blotting, immunofluorescence, and immunohistochemistry to visualize XIRP1 distribution in tissues and assess its involvement in muscle-related pathologies. Studies have linked XIRP1 dysregulation to cardiovascular diseases, including cardiomyopathies, arrhythmias, and muscular dystrophies, highlighting its potential as a biomarker or therapeutic target. Additionally, XIRP1 antibodies aid in exploring its role in developmental biology and regenerative processes. Commercial XIRP1 antibodies are typically validated for specificity, often targeting conserved regions like the Xin repeats. Ongoing research continues to unravel its signaling pathways and interactions with proteins such as β-catenin and vinculin, expanding understanding of muscle biology and disease mechanisms.
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