| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| WB Predicted band size | 52 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human BMP5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于BMP5抗体的模拟参考文献示例(内容为虚构，供参考)：
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1. **文献名称**: *BMP5 in skeletal development: Antibody-based localization and functional analysis*
**作者**: Smith A, et al.
**摘要**: 本研究利用BMP5特异性抗体，通过免疫组化和Western blot技术，揭示了BMP5在小鼠胚胎骨骼发育中的时空表达模式，并证明其通过调控成骨细胞分化影响骨形成。
2. **文献名称**: *A novel monoclonal antibody against BMP5 for cancer metastasis studies*
**作者**: Chen L, et al.
**摘要**: 文章报道了一种新型BMP5单克隆抗体的开发，验证了其在人肺癌组织中的特异性结合能力，并发现BMP5高表达与肿瘤细胞侵袭性转移相关。
3. **文献名称**: *BMP5 antibody blockade attenuates fibrosis in a murine model*
**作者**: Gupta R, et al.
**摘要**: 通过使用中和性BMP5抗体抑制其信号通路，研究者在小鼠模型中显著减轻了肝纤维化程度，提示BMP5可能成为纤维化疾病的治疗靶点。
4. **文献名称**: *Comparative analysis of BMP family antibodies in developmental biology*
**作者**: Tanaka K, et al.
**摘要**: 系统比较了包括BMP5抗体在内的多种BMP家族抗体在斑马鱼胚胎中的交叉反应性和特异性，为发育生物学研究提供了抗体选择指南。
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建议通过PubMed、Google Scholar等平台检索真实文献，关键词如“BMP5 antibody”、“BMP5 immunohistochemistry”或“BMP5 signaling”。
The BMP5 (Bone Morphogenetic Protein 5) antibody is a tool used to detect and study the BMP5 protein, a member of the transforming growth factor-beta (TGF-β) superfamily. BMP5 plays critical roles in embryonic development, tissue homeostasis, and organogenesis, particularly in skeletal and cartilage formation. It regulates cellular processes such as proliferation, differentiation, and apoptosis by signaling through SMAD-dependent pathways and interacting with specific serine/threonine kinase receptors. Dysregulation of BMP5 has been implicated in developmental disorders, fibrotic diseases, and certain cancers, making it a focus of both basic and clinical research.
BMP5 antibodies are widely utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to visualize protein expression, localization, and dynamics in various tissues. These antibodies help elucidate BMP5's involvement in disease mechanisms, such as its dual roles in tumor suppression or progression, depending on context. Researchers also employ neutralizing BMP5 antibodies to inhibit its activity in vitro or in vivo, enabling functional studies.
Validated for specificity and sensitivity, BMP5 antibodies are essential for advancing understanding of BMP signaling networks and their therapeutic targeting. Their applications span developmental biology, regenerative medicine, and oncology, highlighting their versatility in bridging molecular insights with potential clinical interventions.
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