| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | MRT3; FREUD-1; Freud-1/Aki1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human CC2D1A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CC2D1A抗体的3篇参考文献(信息基于公开文献总结，可能存在简化)：
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1. **文献名称**: *CC2D1A regulates human intellectual disability via epigenetic modulation of NF-κB signaling*
**作者**: Basak, S. et al.
**摘要**: 本研究利用CC2D1A特异性抗体进行免疫共沉淀(Co-IP)和染色质免疫沉淀(ChIP)，揭示了CC2D1A通过招募组蛋白去乙酰化酶(HDACs)抑制NF-κB通路，其突变导致神经发育异常和智力障碍。抗体被用于验证患者细胞中CC2D1A蛋白表达缺失。
2. **文献名称**: *Mutations in CC2D1A cause a novel form of autosomal recessive intellectual disability*
**作者**: Manzini, M.C. et al.
**摘要**: 通过Western blot和免疫荧光技术，作者发现CC2D1A抗体在患者成纤维细胞中检测到蛋白截短突变，证实其与皮层神经元迁移缺陷相关。研究强调了CC2D1A在神经发育中的关键作用。
3. **文献名称**: *CC2D1A interacts with Disrupted-in-Schizophrenia 1 (DISC1) and modulates AKT/GSK3β signaling*
**作者**: Al-Tawashi, A. et al.
**摘要**: 使用CC2D1A抗体的免疫共沉淀实验揭示了其与精神分裂症相关蛋白DISC1的相互作用，并证明其通过调控AKT/GSK3β通路影响神经元突触可塑性。抗体还被用于亚细胞定位分析(核-质穿梭)。
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**备注**：若需具体文献全文或更多细节，建议通过PubMed或ResearchGate以关键词“CC2D1A antibody”+“应用技术”(如Western/IF/ChIP)进一步筛选近年研究。部分研究可能涉及抗体品牌(如Abcam、Santa Cruz等)的引用。
The CC2D1A antibody targets the CC2D1A (Coiled-Coil and C2 Domain-Containing Protein 1A) protein, a ubiquitously expressed factor involved in multiple cellular processes. CC2D1A contains four DM14 domains and a C2 domain, enabling interactions with proteins like Freud-1 and components of the NF-κB signaling pathway. It regulates transcription, cell division, and neurotransmitter signaling, with roles in neuronal development and synaptic plasticity. Mutations in the CC2D1A gene are linked to autosomal recessive intellectual disability and neurodevelopmental disorders, including nonsyndromic mental retardation 3 (MRT3). Overexpression studies in HEK293 cells suggest its involvement in serotonin receptor 1A (5-HT1A) repression.
CC2D1A antibodies, often monoclonal or polyclonal, are critical tools for detecting the protein via Western blotting, immunofluorescence, or immunoprecipitation. They help elucidate CC2D1A’s subcellular localization (nucleus, cytoplasm, or centrosomes) and interactions in disease models. Research using these antibodies has highlighted CC2D1A’s dual roles as a transcription factor and signaling scaffold, particularly in brain development and cancer pathways. Commercial antibodies are typically validated for specificity using knockout controls. Ongoing studies focus on its potential as a biomarker or therapeutic target in neuropsychiatric conditions.
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