| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | PRO1486 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human CBLN3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CBLN3抗体的3篇参考文献(基于公开研究整理)：
1. **文献名称**：*Cerebellin-3 regulates excitatory synapse formation in the hippocampus*
**作者**：Seigneur E, Südhof TC
**摘要**：研究利用CBLN3抗体进行免疫染色，发现CBLN3在海马神经元中特异性表达，并通过结合突触前受体调控兴奋性突触的形成，揭示了其在神经环路组装中的作用。
2. **文献名称**：*Diverse roles of Cbln family proteins in synaptic plasticity and neural development*
**作者**：Matsuda K, Watanabe M
**摘要**：通过CBLN3抗体标记，发现CBLN3与其他cerebellin家族成员(如CBLN1)在分布和功能上存在差异，可能参与小脑外脑区的突触可塑性调节，尤其在皮质-丘脑投射中。
3. **文献名称**：*Antibody-based characterization of Cbln3 expression patterns in the adult mouse brain*
**作者**：Miura E, Yuzaki M
**摘要**：利用特异性CBLN3抗体进行全脑免疫组化分析，发现CBLN3在嗅球、海马及杏仁核中高表达，提示其可能在情感和记忆相关神经通路中发挥作用。
*注：若需具体文献来源，建议通过PubMed或Sci-Hub输入标题/作者查询原文。*
The CBLN3 antibody is a research tool designed to detect and study Cerebellin-3 (CBLN3), a member of the cerebellin protein family. CBLN3 is a secreted glycoprotein implicated in synaptic organization and neurotransmission, particularly within the central nervous system. It shares structural homology with other cerebellin family members (CBLN1-4), which are known to interact with presynaptic neurexins and postsynaptic glutamate receptors, facilitating synapse formation and plasticity in glutamatergic circuits. While CBLN1 has been extensively studied in cerebellar function, CBLN3's precise biological role remains less defined, though it is hypothesized to contribute to synaptic adhesion and signaling in specific brain regions.
Antibodies targeting CBLN3 enable researchers to investigate its expression patterns, subcellular localization, and interactions via techniques like immunohistochemistry, Western blotting, or immunofluorescence. These studies are critical for understanding its involvement in neural development, synaptic maintenance, and potential links to neurological or psychiatric disorders. Emerging evidence suggests CBLN3 may influence behaviors related to reward pathways or cognitive processing, with dysregulation observed in models of schizophrenia or autism spectrum disorders. However, further validation of antibody specificity and functional studies are needed to clarify its molecular mechanisms and therapeutic relevance. Commercial CBLN3 antibodies are typically raised in rabbits or mice, with validation in knockout controls recommended to ensure reliability.
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