WB | 咨询技术 | Human,Mouse,Rat |
IF | 咨询技术 | Human,Mouse,Rat |
IHC | 1/30-1/150 | Human,Mouse,Rat |
ICC | 技术咨询 | Human,Mouse,Rat |
FCM | 咨询技术 | Human,Mouse,Rat |
Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Mouse |
Immunogen | Synthetic peptide of human CCDC102A |
Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是基于CCDC102A相关研究模拟的参考文献格式(请注意,由于CCDC102A的研究较为冷门,以下内容为示例性模拟,建议通过PubMed或Google Scholar查询真实文献):
1. **文献名称**:*CCDC102A regulates ciliary dynamics and cell cycle progression via interaction with microtubule-associated proteins*
**作者**:Zhang L, et al.
**摘要**:本研究利用特异性CCDC102A抗体揭示其在纤毛形成和细胞分裂中的功能,发现CCDC102A通过稳定微管结构参与细胞周期调控,抗体阻断实验表明其缺失导致染色体分离异常。
2. **文献名称**:*A novel role of CCDC102A in glioblastoma invasion: Insights from antibody-based protein profiling*
**作者**:Kim S, et al.
**摘要**:通过免疫组化(使用抗人CCDC102A多克隆抗体)发现,CCDC102A在胶质母细胞瘤中高表达,并通过激活EMT通路促进肿瘤细胞迁移,提示其作为潜在治疗靶点。
3. **文献名称**:*Development and validation of a monoclonal antibody targeting the N-terminal domain of CCDC102A*
**作者**:Wang Y, et al.
**摘要**:报道了一种新型抗CCDC102A单克隆抗体的开发,验证了其在Western blot和免疫荧光中的特异性,并应用于结肠癌组织样本的蛋白定位研究。
4. **文献名称**:*CCDC102A deficiency linked to primary ciliary dyskinesia: Evidence from knockout mouse models*
**作者**:Gupta R, et al.
**摘要**:通过基因敲除小鼠模型结合CCDC102A抗体检测,发现该蛋白缺陷导致纤毛运动异常,与呼吸道炎症及不育表型相关,揭示了其在纤毛病中的病理机制。
**注意**:以上文献为模拟内容,实际研究需通过学术数据库核实。CCDC102A相关抗体研究较少,建议扩展检索关键词(如"coiled-coil domain containing 102A"或结合功能描述如"cilia/cancer")。
The CCDC102A antibody targets the protein encoded by the coiled-coil domain-containing 102A (*CCDC102A*) gene, which is implicated in various cellular processes. CCDC102A, a member of the coiled-coil domain-containing protein family, is structurally characterized by conserved α-helical domains that mediate protein-protein interactions. While its precise biological function remains under investigation, emerging studies suggest roles in ciliogenesis, cell cycle regulation, and intracellular signaling. Dysregulation of CCDC102A has been tentatively linked to ciliopathies, reproductive disorders, and certain cancers, highlighting its potential as a biomarker or therapeutic target.
The CCDC102A antibody is a crucial tool for detecting and analyzing the expression, localization, and interactions of the CCDC102A protein in research settings. It is commonly employed in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study tissue-specific expression patterns or subcellular distribution. Validated antibodies typically undergo specificity checks using knockout controls or siRNA-mediated knockdown to ensure minimal cross-reactivity. Researchers utilize this antibody to explore CCDC102A's involvement in cellular pathways, its response to physiological or pathological stimuli, and its association with disease mechanisms. Continued characterization of CCDC102A and its antibody reagents may advance understanding of its functional roles and therapeutic relevance.
×