| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ARG2; Arginase-2; Type II arginase;;ARG2 |
| WB Predicted band size | 39 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human ARG2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是假设性的Arg2抗体相关参考文献示例(请注意，实际文献需通过学术数据库验证)：
1. **"Arginase II contributes to oxidative stress in Alzheimer's disease neurons"**
- Author: Smith A, et al.
- 摘要：研究使用Arg2抗体检测阿尔茨海默病患者脑组织中Arg2蛋白表达升高，发现其通过精氨酸代谢加剧神经元氧化应激。
2. **"Tumor-associated Arg2 expression drives immunosuppression via T-cell dysfunction"**
- Author: Chen L, et al.
- 摘要：通过Arg2抗体阻断肿瘤微环境中的Arg2活性，逆转T细胞功能抑制，提示其作为癌症免疫治疗潜在靶点。
3. **"Macrophage polarization regulated by Arginase 2 in metabolic syndrome"**
- Author: Kim J, et al.
- 摘要：利用Arg2抗体及基因敲除技术，揭示Arg2通过调控巨噬细胞M2极化促进肥胖相关炎症的机制。
4. **"Mitochondrial Arg2 modulates ischemia-reperfusion injury in the heart"**
- Author: Wang Y, et al.
- 摘要：通过Arg2抗体检测心肌线粒体Arg2水平，发现其过表达加重缺血再灌注损伤，靶向抑制可改善心脏功能。
**建议**：实际研究中请使用PubMed、Web of Science等平台，以关键词“Arginase 2 antibody” + 研究领域(如cancer, neurodegeneration)检索最新文献，优先选择高被引或近5年论文。
**Background of Arginase 2 (Arg2) Antibodies**
Arginase 2 (Arg2), a mitochondrial enzyme encoded by the *ARG2* gene, is one of two isoforms (Arg1 and Arg2) that catalyze the hydrolysis of L-arginine to urea and L-ornithine, a critical step in the urea cycle and polyamine biosynthesis. Unlike Arg1. which is cytosolic and liver-specific, Arg2 is expressed in extrahepatic tissues, including kidneys, prostate, and immune cells, and plays roles in modulating cellular processes like proliferation, apoptosis, and immune regulation.
Arg2 has gained attention for its involvement in pathological conditions. Overexpression of Arg2 is linked to endothelial dysfunction in cardiovascular diseases, tumor progression via immunosuppression in the tumor microenvironment, and metabolic disorders such as diabetes. Its role in depleting extracellular L-arginine, a substrate for nitric oxide synthases (NOS), impacts nitric oxide (NO) production, influencing vascular tone and immune responses.
Arg2-specific antibodies are essential tools for detecting and quantifying Arg2 expression in research. They enable studies on its tissue distribution, subcellular localization, and dysregulation in diseases. Applications include Western blotting, immunohistochemistry, and flow cytometry. Recent studies also explore Arg2 as a therapeutic target, with antibodies aiding in validating inhibitors or gene-silencing approaches.
Overall, Arg2 antibodies are pivotal in elucidating the enzyme’s biological functions and its potential as a biomarker or target in disease contexts.
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