关键信息
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基因名
NPSR
- 应用
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别名
ASRT2; GPR154; GPRA; NPSR1; PGR14; VRR1; G Protein-Coupled Receptor For Asthma Susceptibility; G Protein-Coupled Receptor 154; G-protein coupled receptor PGR14
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种属
Human
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6W5P4
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表达区间
Met1~Gln52
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分子量
36kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
NPSR, or Neurokinin Receptor 1, is a G protein-coupled receptor (GPCR) that plays a significant role in various physiological processes, including pain perception, stress response, and neurogenic inflammation. Understanding the structure and function of NPSR is crucial for the development of targeted therapies for conditions such as chronic pain, anxiety, and respiratory disorders. The study of NPSR as a recombinant protein involves the expression, purification, and functional characterization of this receptor to investigate its signaling pathways and interactions with ligands. Recent advancements in biotechnology have enabled the production of NPSR as a recombinant protein, enhancing our ability to study its pharmacological properties and functional mechanisms in detail. This research is pivotal for drug discovery efforts aimed at modulating NPSR activity, potentially leading to novel therapeutic interventions. The elucidation of NPSR's structure and its interaction with endogenous ligands provides insight into its role in health and disease, paving the way for innovative approaches in treating disorders linked to dysregulated neurokinin signaling. This foundational research contributes to a deeper understanding of GPCR biology and opens avenues for the development of specific NPSR-targeted drugs, with implications for improving patient outcomes in related conditions.
