Recombinant Human CCL24 protein

中文名： C-C基序趋化因子24(CCL24)重组蛋白
别名： CCL24；MPIF2；；C-C motif chemokine 24

货号: PA1000-4194

Price： ￥询价

20μg 50μg 100μg ＞100μg

数量：

大包装询价

产品详情

纯度	>97%SDS-PAGE.
种属	Human
靶点	CCL24
Uniprot No	O00175
内毒素	< 0.01EU/μg
表达宿主	E.coli
表达区间	27-104aa
氨基酸序列	VVIPSPCCMF FVSKRIPENR VVSYQLSSRS TCLKAGVIFT TKKGQQFCGD PKQEWVQRYM KNLDAKQKKA SPRARAVA
预测分子量	8.8 kDa
蛋白标签	His tag N-Terminus
缓冲液	PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
稳定性 & 储存条件	Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶	Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

参考文献

以下是关于CCL24重组蛋白的3篇示例参考文献(内容为模拟概括，建议通过数据库验证具体信息)：

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1. **文献名称**：*Human Eotaxin (CCL24) as a Mediator of Eosinophil Chemotaxis*

**作者**：Garcia-Zepeda EA 等

**摘要**：该研究报道了重组CCL24蛋白的制备及其对嗜酸性粒细胞的趋化作用，证实其在过敏性炎症中通过结合CCR3受体介导细胞迁移。

2. **文献名称**：*CCL24 Promotes Liver Fibrosis via Recruitment of Inflammatory Macrophages*

**作者**：Hieshima K 等

**摘要**：通过体外和动物实验，研究发现重组CCL24蛋白可激活肝星状细胞并招募促纤维化巨噬细胞，揭示了其在肝纤维化中的病理机制。

3. **文献名称**：*Expression and Functional Characterization of Recombinant CCL24 in Cancer Models*

**作者**：Chen L 等

**摘要**：该文献描述了在大肠杆菌中高效表达重组CCL24的方法，并证明其在肿瘤微环境中促进血管生成和免疫抑制性细胞浸润的作用。

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**提示**：以上内容为概括性示例，实际文献需通过PubMed、Google Scholar等平台检索关键词(如“Recombinant CCL24”“CCL24 function”)获取准确信息。

背景信息

CCL24 (C-C motif chemokine ligand 24), also known as eotaxin-2. is a small secretory protein belonging to the CC chemokine family. It plays a critical role in immune regulation by recruiting specific leukocytes, particularly eosinophils, Th2 lymphocytes, and basophils, to sites of inflammation or injury. This chemokine exerts its biological effects primarily through binding to its cognate receptor CCR3. a G-protein-coupled receptor expressed on the surface of target cells. The CCL24-CCR3 axis is implicated in the pathophysiology of various inflammatory and fibrotic disorders, including asthma, allergic diseases, hepatic fibrosis, and certain cancers.

Recombinant CCL24 protein is engineered using biotechnological platforms, such as Escherichia coli or mammalian expression systems, to produce high-purity, biologically active forms of the protein for research and therapeutic development. Its production typically involves gene cloning, expression optimization, and purification techniques like affinity chromatography. Researchers utilize recombinant CCL24 to study immune cell migration mechanisms, inflammatory pathways, and tissue remodeling processes in vitro and in vivo. In drug discovery, it serves as a tool for screening CCR3 antagonists or evaluating therapeutic candidates targeting eosinophil-mediated diseases.

Recent studies highlight CCL24's dual role in both promoting pathological inflammation and facilitating tissue repair, making it a nuanced therapeutic target. Elevated CCL24 levels have been observed in fibrotic tissues and tumor microenvironments, suggesting diagnostic or prognostic potential. However, challenges remain in understanding its context-dependent functions and optimizing targeted therapies due to complex cross-talk with other chemokines and receptors. Ongoing research aims to unravel its pleiotropic effects and explore clinical applications in precision medicine.