| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Fructose-bisphosphate aldolase C, Brain-type aldolase, ALDOC, ALDC |
| Entrez GeneID | 230 |
| WB Predicted band size | 39.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This ALDOC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 300-333 amino acids from the C-terminal region of human ALDOC. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于ALDOC抗体的3篇模拟参考文献示例(非真实文献，仅供格式参考)：
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1. **标题**: "Aldolase C (ALDOC) as a Novel Biomarker in Glioblastoma: Immunohistochemical Analysis"
**作者**: Smith J, et al.
**摘要**: 研究通过免疫组化分析发现ALDOC在胶质瘤组织中特异性高表达，提示其作为胶质瘤诊断标志物的潜力，并验证了ALDOC抗体在区分肿瘤与正常脑组织中的敏感性。
2. **标题**: "ALDOC Antibody-Based Detection of Neurodegenerative Changes in Alzheimer's Disease Models"
**作者**: Lee H, et al.
**摘要**: 该文献利用ALDOC抗体检测阿尔茨海默病小鼠模型的脑组织，发现ALDOC表达水平与神经元损伤程度呈负相关，表明其在神经退行性病变中的潜在调控作用。
3. **标题**: "Upregulation of Aldolase C in Retinal Ischemia: Implications for Diabetic Retinopathy"
**作者**: García-Ruiz A, et al.
**摘要**: 研究通过Western blot和免疫荧光技术，证实ALDOC在缺血性视网膜病变中表达上调，ALDOC抗体可作为研究代谢异常相关眼病的工具。
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注：以上文献为示例性内容，实际引用时需检索PubMed、Google Scholar等平台获取真实研究。
The ALDOC antibody targets aldolase C (ALDOC), a brain-specific isoform of the glycolytic enzyme aldolase, which catalyzes the cleavage of fructose-1.6-bisphosphate into triose phosphates. Primarily expressed in the brain, particularly in cerebellar Purkinje cells and hippocampal neurons, ALDOC plays a critical role in energy metabolism within neural tissues. Unlike its isoforms ALDOA (muscle) and ALDOB (liver), ALDOC's expression is tightly linked to neurodevelopment and synaptic function.
ALDOC antibodies are widely used in neuroscience research to study protein localization, expression levels, and metabolic dysregulation in neurological disorders. Reduced ALDOC levels have been associated with ataxia, epilepsy, and neurodegenerative conditions like Alzheimer’s disease. Additionally, ALDOC is implicated in cancers, such as glioblastoma and neuroblastoma, where its aberrant expression may correlate with tumor aggressiveness or metabolic adaptation.
These antibodies serve as vital tools in techniques like immunohistochemistry, Western blotting, and immunofluorescence, enabling insights into disease mechanisms and potential biomarker discovery. Recent studies also explore ALDOC's non-glycolytic roles, including regulation of cytoskeletal dynamics and cellular stress responses, broadening its therapeutic relevance.
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