Rabbit Polyclonal c-Cbl(phospho-Tyr700) Antibody

The c-Cbl (phospho-Tyr700) antibody is designed to specifically detect the phosphorylated form of the Casitas B-lineage lymphoma (c-Cbl) protein at tyrosine residue 700. c-Cbl is a multifunctional adaptor protein and E3 ubiquitin ligase involved in regulating signal transduction pathways, particularly those downstream of receptor tyrosine kinases (RTKs). Phosphorylation at Tyr700 is a critical post-translational modification that modulates c-Cbl's activity, often occurring in response to extracellular stimuli such as growth factors or antigen receptor engagement. This phosphorylation event facilitates conformational changes, enabling c-Cbl to interact with downstream signaling molecules, including phosphoinositide 3-kinase (PI3K) and Crk proteins, thereby influencing cellular processes like proliferation, differentiation, and apoptosis. Dysregulation of c-Cbl activity or phosphorylation has been implicated in oncogenesis, immune disorders, and metabolic diseases. The c-Cbl (phospho-Tyr700) antibody is widely used in research to investigate RTK signaling dynamics, ubiquitination-mediated receptor degradation, and pathological mechanisms in cancer or immune dysregulation. Its specificity for the phosphorylated state allows precise tracking of c-Cbl activation in cell lysates or tissue samples via techniques like Western blotting, immunoprecipitation, or immunofluorescence.