Rabbit Polyclonal Niban(Phospho-Ser602) Antibody

The Niban (Phospho-Ser602) antibody is designed to detect FAM129A, a protein encoded by the FAM129A gene, also known as Niban. FAM129A is a member of the FAM129 family and plays a role in regulating apoptosis, particularly under endoplasmic reticulum (ER) stress. It is implicated in cellular stress responses and cancer progression, with elevated expression observed in various malignancies. The phosphorylation at Serine 602 (Ser602) is a critical post-translational modification linked to FAM129A's functional regulation. This modification may influence its interaction with signaling pathways, such as the AMP-activated protein kinase (AMPK) pathway, which is involved in energy homeostasis and stress adaptation. The Niban (Phospho-Ser602) antibody specifically recognizes this phosphorylated epitope, enabling researchers to study the activation status and mechanistic role of FAM129A in stress response, apoptosis evasion, and tumorigenesis. It is commonly used in techniques like Western blotting and immunohistochemistry to assess phosphorylation dynamics in cell lines or tissue samples. Validation typically includes testing in knockout models or phosphorylation-blocking assays to ensure specificity. This antibody serves as a valuable tool for exploring FAM129A's contribution to cancer biology and cellular stress mechanisms.