Rabbit Polyclonal MYT1(Phospho-Ser83) Antibody

The MYT1 (Phospho-Ser83) antibody detects the phosphorylated form of MYT1 at serine residue 83. a post-translational modification critical for regulating its functional activity. MYT1. a member of the zinc finger transcription factor family, plays roles in neuronal development, cell differentiation, and maintaining stem cell pluripotency. It binds to DNA to repress gene expression, particularly influencing pathways involved in cell cycle control and neural specification. Phosphorylation at Ser83 is thought to modulate MYT1’s transcriptional activity, cellular localization, or interactions with co-regulators, though the precise mechanisms remain under investigation. This modification may be linked to signaling pathways such as MAPK or CDKs, which are active during specific developmental stages or stress responses. The MYT1 (Phospho-Ser83) antibody is widely used in neuroscience and cancer research, as MYT1 dysregulation has been implicated in neurodevelopmental disorders and certain malignancies. Researchers employ this antibody in techniques like Western blotting, immunofluorescence, or ChIP-seq to study phosphorylation-dependent MYT1 dynamics in cellular models or tissue samples. Its specificity is typically validated using phosphorylation-deficient mutants or phosphatase-treated lysates to ensure accurate detection. Understanding MYT1 phosphorylation provides insights into its role in balancing proliferation and differentiation during tissue development and disease.