Rabbit Polyclonal BL-CAM(Phospho-Tyr807) Antibody

The BL-CAM (Phospho-Tyr807) antibody is designed to detect the phosphorylated form of the basal cell adhesion molecule (BL-CAM), also known as Lutheran glycoprotein (Lu/BCAM), at tyrosine residue 807. BL-CAM is a transmembrane glycoprotein belonging to the immunoglobulin superfamily, primarily expressed in red blood cells, endothelial cells, and certain epithelial tissues. It plays a role in cell adhesion, migration, and signaling by interacting with laminin α5 in the extracellular matrix. Phosphorylation at Tyr807 is a critical post-translational modification linked to intracellular signaling pathways, particularly under physiological or pathological conditions involving cellular stress, mechanical stimulation, or disease states like sickle cell disease and cancers. This antibody is widely used in research to study the activation status of BL-CAM and its involvement in processes such as erythropoiesis, tumor metastasis, and vascular remodeling. By specifically recognizing the phosphorylated epitope, it enables the assessment of BL-CAM's functional regulation through tyrosine kinase signaling, offering insights into molecular mechanisms underlying cell adhesion dynamics and potential therapeutic targets. Applications include Western blotting, immunofluorescence, and immunohistochemistry in both physiological and disease-model contexts.