| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | p150; c-ABL; EC 2.7.10.2; |
| Entrez GeneID | 25; |
| WB Predicted band size | 135kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 204 (K-L-Y(p)-V-S) derived from Human c-Abl. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Abl (Phospho-Tyr204)抗体的3篇示例参考文献(注：文献为模拟示例，实际需根据具体研究补充)：
1. **"Phosphorylation of Abl at Tyr204 regulates kinase activation and substrate specificity"**
*Authors: Zhang et al.*
摘要：本研究通过开发特异性抗Abl (Tyr204磷酸化)抗体，揭示了该位点的磷酸化在Abl激酶活性调控中的作用，并证明其与细胞迁移信号通路的关联。
2. **"A phosphospecific antibody for Abl Tyr204 reveals its role in DNA damage response"**
*Authors: Thompson et al.*
摘要：文章报道了一种高特异性抗体的开发，用于检测Abl在Tyr204位点的磷酸化，并发现该修饰在DNA损伤后调控细胞周期检查点的关键功能。
3. **"Targeting Abl phosphorylation at Tyr204 in chronic myeloid leukemia therapy"**
*Authors: Rivera et al.*
摘要：通过Abl (Tyr204磷酸化)抗体分析临床样本，发现该位点磷酸化水平与伊马替尼耐药性相关，为白血病治疗提供了新靶点。
建议通过PubMed或Google Scholar以关键词 **"Abl Tyr204 phosphorylation antibody"** 或 **"Phospho-Tyr204 Abl"** 检索真实文献，并优先选择抗体验证相关的高影响力论文。
The Abl (Phospho-Tyr204) antibody is a research tool designed to detect the phosphorylated form of the Abelson (Abl) tyrosine kinase at tyrosine residue 204. Abl kinases, including c-Abl (ABL1) and Arg (ABL2), are non-receptor tyrosine kinases involved in regulating cell proliferation, differentiation, adhesion, and stress responses. Phosphorylation at specific tyrosine residues, such as Tyr204 in c-Abl, is critical for modulating its enzymatic activity and interaction with downstream signaling molecules. This phosphorylation event typically occurs during kinase activation, often triggered by cellular stimuli like DNA damage or growth factor signaling.
The Tyr204 site lies within the kinase domain of c-Abl, and its phosphorylation is associated with conformational changes that enhance catalytic activity. Dysregulation of Abl kinases, particularly through hyperactivation (e.g., BCR-ABL fusion in chronic myeloid leukemia), is linked to cancer pathogenesis. The Abl (Phospho-Tyr204) antibody is widely used in Western blotting, immunohistochemistry, and immunofluorescence to study Abl activation status in cellular models or disease contexts, such as leukemia research or investigations of tyrosine kinase inhibitor resistance. It serves as a key reagent for understanding Abl-related signaling pathways and evaluating therapeutic targeting strategies.
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