Rabbit Polyclonal CD44(Phospho-Ser706) Antibody

The CD44 (Phospho-Ser706) antibody is a specialized tool used to detect the phosphorylated form of CD44 at serine residue 706. CD44 is a transmembrane glycoprotein involved in cell-cell and cell-matrix interactions, playing critical roles in cellular adhesion, migration, signaling, and tumor metastasis. Its activity is often regulated by post-translational modifications, including phosphorylation. Phosphorylation at Ser706 has been implicated in modulating CD44’s interaction with cytoskeletal components and extracellular ligands, potentially influencing cancer progression, immune response, or stem cell regulation. This phosphorylation event may be triggered by signaling pathways like PKC or MAPK, linking it to cellular processes such as proliferation, survival, or epithelial-mesenchymal transition (EMT). Researchers use this antibody to study CD44 activation states in contexts like cancer metastasis, inflammatory diseases, or tissue repair. Validated applications typically include Western blotting, immunofluorescence, or immunohistochemistry, often in models of breast, colon, or pancreatic cancers. Proper controls, such as non-phosphorylated CD44 detection or phosphatase-treated samples, are essential to confirm specificity. The antibody’s utility lies in elucidating mechanisms of CD44-mediated signaling and its pathological implications.