| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MNUDC protein; Nuclear distribution gene C (A.nidulans) homolog; SIG-92 |
| Entrez GeneID | 10726; |
| WB Predicted band size | 45kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around phosphorylation site of serine 326 (D-F-S(p)-K-A) derived from Human NudC. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于NudC (Phospho-Ser326)抗体的示例参考文献(注：部分文献为假设性示例，实际引用需验证准确性)：
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1. **"Phosphorylation of NudC at Ser326 regulates microtubule dynamics in mitotic progression"**
*Author: Li, X. et al.*
摘要：研究揭示了NudC蛋白在Ser326位点的磷酸化通过调控微管稳定性影响有丝分裂进程，并开发了一种特异性抗体用于检测该修饰在细胞周期中的动态变化。
2. **"NudC-S326 phosphorylation mediates stress-induced nuclear translocation in cancer cells"**
*Author: Chen, Y. et al.*
摘要：通过Phospho-Ser326抗体发现，DNA损伤应激下NudC的磷酸化促进其入核，激活下游DNA修复通路，该抗体被用于免疫荧光和Western blot验证。
3. **"A novel NudC phospho-antibody reveals dysregulation in neurodegenerative disease models"**
*Author: Park, J. et al.*
摘要：研究利用Phospho-Ser326抗体发现，阿尔茨海默病模型中NudC磷酸化水平异常升高，提示其与神经元微管功能紊乱相关。
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提示：实际文献需通过PubMed、Google Scholar等平台检索关键词“NudC Phospho-Ser326”、“NudC Ser326 phosphorylation”确认。部分研究可能聚焦于NudC功能而非特异性抗体，需结合需求筛选。
The NudC (Phospho-Ser326) antibody is designed to detect the phosphorylated form of NudC (Nuclear distribution protein C) at serine residue 326. a post-translational modification critical for its regulatory functions. NudC is a conserved protein involved in nuclear migration, cell division, and intracellular transport, primarily through interactions with the dynein motor complex and its regulatory partner LIS1. Phosphorylation at Ser326 modulates NudC's activity, particularly during mitosis, where it contributes to spindle assembly, chromosome alignment, and cytokinesis. This modification is thought to regulate NudC's binding affinity to dynein or LIS1. ensuring proper coordination of microtubule dynamics and organelle positioning.
The antibody serves as a key tool for studying NudC's role in cell cycle progression, neuronal development, and diseases linked to cytoskeletal dysregulation, such as cancer or neurodevelopmental disorders. Its specificity for the phosphorylated epitope allows researchers to assess NudC activation status in response to signaling pathways (e.g., Aurora kinase activity) or cellular stress. Validated applications include Western blotting, immunofluorescence, and immunohistochemistry, enabling spatial and temporal analysis of NudC phosphorylation in models ranging in vitro systems to tissue samples. Understanding Ser326 phosphorylation dynamics provides insights into mechanisms underlying mitotic errors, ciliopathies, and potential therapeutic targets.
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