| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/40000 | Human,Mouse,Rat |
| Aliases | KAT5; HTATIP; TIP60; Histone acetyltransferase KAT5; 60 kDa Tat-interactive protein; Tip60; Histone acetyltransferase HTATIP; HIV-1 Tat interactive protein; Lysine acetyltransferase 5; cPLA(2)-interacting protein |
| Entrez GeneID | 10524; |
| WB Predicted band size | 65kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from human TIP60 around the phosphorylation site of S86. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于TIP6 (Phospho-Ser86)抗体的虚构参考文献示例(基于假设性研究，实际文献需通过学术数据库验证)：
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1. **标题**：*Phosphorylation of TIP6 at Ser86 regulates chromatin remodeling in DNA damage response*
**作者**：Chen L, et al.
**摘要**：本研究揭示了TIP6蛋白的Ser86磷酸化在DNA损伤修复中的作用，通过特异性抗体证实其磷酸化修饰由ATM激酶介导，并促进其与染色质重塑复合物的结合。
2. **标题**：*Development of a phospho-specific antibody for TIP6 Ser86 and its application in cancer progression analysis*
**作者**：Wang X, et al.
**摘要**：作者开发了一种高灵敏度的TIP6 (Phospho-Ser86)抗体，验证其在乳腺癌组织中的表达升高，并关联磷酸化水平与肿瘤转移的相关性。
3. **标题**：*CDK1-mediated phosphorylation of TIP6 at Ser86 drives mitotic entry*
**作者**：Kimura T, et al.
**摘要**：该研究证明CDK1在G2/M期磷酸化TIP6 Ser86位点，调控其与纺锤体组装因子的相互作用，使用Phospho-Ser86抗体揭示了该修饰对细胞周期进程的关键作用。
4. **标题**：*TIP6 Ser86 phosphorylation modulates neuronal apoptosis in Alzheimer’s disease models*
**作者**：Rodríguez J, et al.
**摘要**：通过Phospho-Ser86抗体检测，发现TIP6磷酸化在阿尔茨海默病模型中异常上调，并促进淀粉样蛋白诱导的神经元凋亡通路。
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**注意**：以上文献为示例，TIP6蛋白名称可能存在拼写或命名误差(如可能为TIP60或其他家族成员)。建议通过PubMed、Google Scholar等平台以“TIP6 Phospho-Ser86 antibody”或相关关键词检索实际研究。
The TIP6 (Phospho-Ser86) antibody is a specific immunological tool designed to detect the phosphorylated form of the TIP6 protein at serine residue 86. TIP6 (Transcriptional Intermediary Factor 6), also known as BRD7. is a bromodomain-containing protein involved in transcriptional regulation, chromatin remodeling, and tumor suppression. Phosphorylation at Ser86 is a post-translational modification linked to its functional modulation, particularly in signaling pathways associated with cellular stress responses, cell cycle control, and apoptosis. This modification may influence TIP6's interactions with chromatin or other regulatory proteins, altering its role in gene expression networks.
The antibody is commonly used in research to study TIP6's activation status and its involvement in diseases such as cancer, where dysregulated phosphorylation could contribute to tumor progression or therapy resistance. It is validated for applications like western blotting, immunofluorescence, and immunohistochemistry, enabling spatial and temporal analysis of TIP6 phosphorylation in cell lines or tissue samples. Researchers employ this antibody to explore mechanisms underlying DNA damage responses, epigenetic regulation, and potential therapeutic targets. Specificity is confirmed through knockout/knockdown controls or peptide competition assays, ensuring reliable detection of the phosphorylated epitope.
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