| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200-1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | IL13RA1; IL13R; IL13RA; Interleukin-13 receptor subunit alpha-1; IL-13 receptor subunit alpha-1; IL-13R subunit alpha-1; IL-13R-alpha-1; IL-13RA1; Cancer/testis antigen 19; CT19; CD antigen CD213a1 |
| Entrez GeneID | 3597; |
| WB Predicted band size | 49kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from human IL-13Rα1 around the phosphorylation site of Y405. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是基于假设性数据的参考文献示例(请注意实际文献可能需要通过学术数据库验证)：
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1. **Title**: *Phosphorylation of IL-13Rα1 at Tyr405 regulates STAT6 signaling in asthma*
**Authors**: Smith A, et al.
**Summary**: 研究揭示了IL-13Rα1在Tyr405位点的磷酸化通过招募STAT6促进Th2炎症反应，抗体的特异性验证为哮喘模型中的靶向治疗提供依据。
2. **Title**: *Development of a monoclonal antibody specific for phosphorylated Tyr405 on IL-13Rα1 and its application in glioblastoma*
**Authors**: Chen L, et al.
**Summary**: 报道了一种新型抗体的开发，证实其在胶质母细胞瘤中检测IL-13Rα1磷酸化水平的能力，并关联该位点与肿瘤侵袭性及EGFR通路交互作用。
3. **Title**: *IL-13 receptor α1 tyrosine phosphorylation modulates macrophage polarization in fibrosis*
**Authors**: Kim Y, et al.
**Summary**: 利用Phospho-Tyr405抗体发现，该位点磷酸化通过激活JAK1驱动巨噬细胞M2极化，成为纤维化疾病的潜在生物标志物。
4. **Title**: *Structural basis of IL-13 signaling through IL-13Rα1/IL-4Rα receptor complex*
**Authors**: Wang H, et al.
**Summary**: 通过晶体学与磷酸化抗体验证，阐明Tyr405磷酸化对受体二聚化及下游信号的影响，为靶向疗法提供结构基础。
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**说明**：以上文献为模拟示例，实际研究中可能需要结合具体数据库(如PubMed、Web of Science)检索。若该靶点研究较少，建议扩展至IL-13信号通路或相关受体磷酸化的综述文献。
The IL-13Rα1 (Phospho-Tyr405) antibody is designed to detect the phosphorylated form of interleukin-13 receptor subunit alpha-1 (IL-13Rα1) at tyrosine residue 405. a post-translational modification critical for receptor signaling. IL-13Rα1. a key component of the type II IL-13 receptor complex (paired with IL-4Rα), mediates IL-13 signaling involved in Th2-driven immune responses, including allergy, inflammation, fibrosis, and tumor progression. Phosphorylation of Tyr405 is associated with receptor activation, downstream signal transduction (e.g., STAT6. PI3K/Akt pathways), and regulation of cellular processes like apoptosis, proliferation, and cytokine production.
This antibody is widely used in research to study IL-13/IL-13Rα1 signaling dynamics in diseases such as asthma, atopic dermatitis, pulmonary fibrosis, and cancers (e.g., glioblastoma, colorectal cancer), where IL-13 overexpression or dysregulated receptor activity is implicated. It enables detection of phosphorylated IL-13Rα1 in techniques like Western blotting, immunoprecipitation, or immunofluorescence, helping to elucidate mechanisms of receptor activation, crosstalk with other pathways (e.g., IL-4 signaling), and therapeutic targeting. Specific validation (e.g., knockout controls, phospho-inhibition) is recommended to confirm antibody specificity, as cross-reactivity with related phosphorylated residues or proteins may occur. Its application supports both basic research and preclinical studies for IL-13/IL-13Rα1-targeted therapies.
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