Rabbit Polyclonal p63(Phospho-Ser455) Antibody

The p63 (Phospho-Ser455) antibody is a specialized tool used to detect the phosphorylated form of the p63 protein at serine residue 455. p63. encoded by the TP63 gene, is a transcription factor belonging to the p53 family and plays critical roles in epithelial development, stem cell maintenance, and tissue homeostasis. Unlike its homolog p53. p63 exists as multiple isoforms, with TAp63 and ΔNp63 variants exhibiting distinct functions in cell proliferation, differentiation, and apoptosis. Phosphorylation at specific residues, such as Ser455. modulates p63’s transcriptional activity, stability, or interactions with co-regulators, often in response to cellular stress or signaling pathways. The Phospho-Ser455 epitope is associated with post-translational modifications that regulate p63’s function in contexts like DNA damage response or differentiation. Researchers employ this antibody in techniques like Western blotting, immunohistochemistry, or immunofluorescence to study p63 activation dynamics in diseases such as cancers (e.g., squamous cell carcinomas) or developmental disorders. Its specificity for the phosphorylated state allows insights into signaling pathways (e.g., ATM/ATR kinases) that modulate p63 activity. Validation typically includes testing in cell lines with induced phosphorylation (e.g., via genotoxic stress) and knockout controls. This antibody is particularly valuable in research exploring epithelial biology, tumorigenesis, and regenerative medicine.