Rabbit Polyclonal CaseinKinaseIIβ(Phospho-Ser209) Antibody

Casein Kinase IIβ (CK2β) Phospho-Ser209 antibody is a phosphospecific antibody designed to detect the β-subunit of Casein Kinase II (CK2) when phosphorylated at serine residue 209. CK2 is a ubiquitously expressed serine/threonine kinase composed of two catalytic subunits (α/α') and two regulatory β-subunits. The β-subunit plays a regulatory role, stabilizing the holoenzyme complex, modulating substrate specificity, and influencing subcellular localization. Phosphorylation at Ser209 in CK2β is a post-translational modification implicated in regulating CK2 activity and interactions with cellular partners. This site lies within the acidic loop region of CK2β, and its phosphorylation may influence CK2 holoenzyme assembly, substrate recruitment, or protein-protein interactions. The antibody is commonly used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to study CK2β phosphorylation dynamics in cellular processes such as cell cycle regulation, DNA repair, and apoptosis. Dysregulation of CK2 activity, including phosphorylation-dependent mechanisms, has been linked to cancer, neurodegenerative diseases, and viral infections, making this antibody a valuable tool for investigating CK2-related signaling pathways and disease mechanisms. Specificity for the phosphorylated form ensures accurate detection of activated CK2β in biological samples.