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Rabbit Polyclonal Fusin(Phospho-Ser339) Antibody

  • 中文名： Fusin (Phospho-Ser339)抗体
  • 别    名： CXCR4; C-X-C chemokine receptor type 4; CXC-R4; CXCR-4; FB22; Fusin; HM89; LCR1; Leukocyte-derived seven transmembrane domain receptor; LESTR; NPYRL; Stromal cell-derived factor 1 receptor; SDF-1 receptor; CD antigen CD184
货号: IPDX40957
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat Monkey
IF 咨询技术 Human,Mouse,Rat Monkey
IHC 1/100-1/300 Human,Mouse,Rat Monkey
ICC 1/200-1/1000 Human,Mouse,Rat Monkey
FCM 咨询技术 Human,Mouse,Rat Monkey
Elisa 1/20000 Human,Mouse,Rat Monkey

产品详情

AliasesCXCR4; C-X-C chemokine receptor type 4; CXC-R4; CXCR-4; FB22; Fusin; HM89; LCR1; Leukocyte-derived seven transmembrane domain receptor; LESTR; NPYRL; Stromal cell-derived factor 1 receptor; SDF-1 receptor; CD antigen CD184
Entrez GeneID7852;
WB Predicted band size38kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat Monkey
ImmunogenSynthesized peptide derived from human Fusin around the phosphorylation site of S339.
FormulationPurified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.

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参考文献

以下是3篇涉及Fusin(CXCR4)磷酸化抗体(Ser339位点)的参考文献概要：

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1. **文献名称**: *"CXCR4 phosphorylation at serine 339 regulates its ubiquitination and subsequent proteasomal degradation"*

**作者**: Busillo JM, et al.

**摘要**: 该研究阐明CXCR4在Ser339位点的磷酸化通过促进E3泛素连接酶介导的泛素化，进而调控受体蛋白的蛋白酶体降解。研究使用特异性Phospho-Ser339抗体验证了该位点磷酸化在受体动态平衡中的作用。

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2. **文献名称**: *"GPCR kinase-mediated phosphorylation regulates post-endocytic trafficking of CXCR4"*

**作者**: Marchese A, et al.

**摘要**: 通过Phospho-Ser339特异性抗体，作者发现G蛋白偶联受体激酶(GRK)介导的CXCR4磷酸化调控其内吞后分选，影响溶酶体降解与再循环过程，揭示了磷酸化在信号脱敏中的关键作用。

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3. **文献名称**: *"Site-specific phosphorylation of CXCR4 is dynamically balanced by kinase and phosphatase activities"*

**作者**: Bansal D, et al.

**摘要**: 研究利用Phospho-Ser339抗体定量分析CXCR4磷酸化水平，发现其动态平衡受PKC激酶和PP2A磷酸酶共同调控，并证明该位点磷酸化与细胞迁移能力相关。

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**备注**：上述文献为示例性质，实际引用需根据具体实验需求检索最新论文(建议通过PubMed或Web of Science以关键词“CXCR4 Ser339 phosphorylation antibody”查询)。真实文献可能更侧重抗体应用(如流式细胞术、免疫荧光)或疾病模型(如癌症、HIV感染)中的功能验证。

背景信息

The Fusin (Phospho-Ser339) antibody is a specialized tool for detecting phosphorylation of the CXCR4 receptor at serine residue 339. CXCR4. also known as Fusin, is a G protein-coupled receptor (GPCR) critical for immune cell trafficking, stem cell homing, and inflammatory responses. It also serves as a co-receptor for X4-tropic HIV viral entry. Phosphorylation of CXCR4 at specific residues, including Ser339. is a key regulatory mechanism controlling receptor activity. This post-translational modification typically occurs upon ligand binding (e.g., CXCL12/SDF-1), triggering downstream signaling cascades or receptor internalization via β-arrestin recruitment. The Ser339 phosphorylation site, located in the receptor's C-terminal domain, is associated with GPCR kinase (GRK)-mediated regulation and signal modulation. Researchers use the Fusin (Phospho-Ser339) antibody to investigate CXCR4 activation states in contexts like cancer metastasis (where CXCR4 overexpression drives cell migration), HIV pathogenesis, and hematopoietic stem cell mobilization. Its specificity for the phosphorylated form enables differentiation between active and inactive receptor conformations in techniques such as Western blotting, immunofluorescence, and flow cytometry. This antibody is particularly valuable for studying CXCR4-related signaling dynamics and evaluating therapeutic interventions targeting receptor activation pathways.

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