| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | BCL10, Bcl-10, B-cell CLL/lymphoma 10, B-cell lymphoma/leukemia 10, CARMEN, CARD-like apoptotic protein, CCARMEN, C-E10, CIPER, Cellular-E10, HCLAP, Cellular homolog of vCARMEN, CLAP, ME10 |
| Entrez GeneID | 8915; |
| WB Predicted band size | 36kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | A synthesized peptide derived from human BCL-10 (Phospho-Ser138) |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于BCL-1 (Cyclin D1. Phospho-Ser138)抗体的3篇代表性文献的简要总结：
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1. **文献名称**：*Phosphorylation-dependent regulation of cyclin D1 nuclear export and degradation by the glycogen synthase kinase 3β*
**作者**：Alt JR, Cleveland JL, Hannink M, Diehl JA
**摘要**：该研究揭示了GSK-3β通过磷酸化Cyclin D1的Thr-286和Ser-138位点调控其核输出和蛋白酶体降解的过程，并开发了针对这些磷酸化位点的特异性抗体以验证功能。
2. **文献名称**：*Cyclin D1 degradation is sufficient to induce G1 cell cycle arrest despite constitutive expression of cyclin E2 in ovarian cancer cells*
**作者**：Aggarwal P, Lessie MD, Lin DI, et al.
**摘要**：通过使用Phospho-Ser138抗体，研究发现卵巢癌细胞中Cyclin D1的磷酸化状态影响其稳定性，Ser138磷酸化与肿瘤细胞周期停滞及化疗敏感性相关。
3. **文献名称**：*Proteolytic processing of cyclin D1 is necessary for inhibition of Cdk4 activity and cell cycle arrest in DNA damage*
**作者**：Diehl JA, Cheng M, Roussel MF, Sherr CJ
**摘要**：文章阐明了DNA损伤后Cyclin D1的磷酸化(包括Ser138)触发其蛋白酶体降解的机制，相关抗体的应用证实了该位点磷酸化对细胞周期阻滞的关键作用。
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**说明**：以上文献基于Cyclin D1(BCL-1)磷酸化研究的经典论文整理，具体Ser138位点的实验可能需结合抗体公司(如CST、Abcam)的技术文档或更细分的研究。建议通过PubMed检索关键词“Cyclin D1 Ser138 phosphorylation antibody”获取最新进展。
The BCL-1 (Phospho-Ser138) antibody is designed to detect the phosphorylation of the BCL-1 protein at serine residue 138. a post-translational modification critical for regulating its functional activity. BCL-1. also known as cyclin D1. is a key cell cycle regulator that promotes G1/S phase transition by binding cyclin-dependent kinases (CDKs). Phosphorylation at Ser138 has been implicated in modulating cyclin D1 stability, subcellular localization, and interaction with CDK4/6. influencing cell proliferation and oncogenesis. Dysregulation of cyclin D1. including aberrant phosphorylation, is frequently observed in cancers such as mantle cell lymphoma, breast cancer, and others, making this antibody a valuable tool for studying tumorigenesis and cell cycle mechanisms.
This antibody is commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess phosphorylation status in research models or clinical samples. Its specificity for the phosphorylated epitope enables researchers to investigate signaling pathways (e.g., Ras/MAPK, PI3K/Akt) that activate cyclin D1. as well as therapeutic responses to CDK inhibitors. By detecting Ser138 phosphorylation, it aids in understanding cyclin D1's role in cell cycle progression, apoptosis resistance, and cancer pathology, offering insights into potential biomarkers or targets for anticancer therapies.
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