Rabbit Polyclonal TRF2(Phospho-Thr188) Antibody

The TRF2 (Phospho-Thr188) antibody is a specialized tool used to study the post-translational modification of Telomeric Repeat Binding Factor 2 (TRF2), a critical component of the shelterin complex that safeguards telomeres. TRF2 plays a pivotal role in maintaining telomere integrity by forming T-loop structures that prevent chromosome ends from being recognized as DNA damage. Phosphorylation at threonine 188 (Thr188) is a key regulatory event influencing TRF2’s function. This modification is associated with cell cycle progression, particularly during mitosis, and may modulate TRF2’s ability to bind telomeric DNA or interact with other shelterin proteins. Dysregulation of TRF2 phosphorylation has been implicated in telomere dysfunction, genomic instability, and diseases such as cancer. The TRF2 (Phospho-Thr188) antibody specifically detects this phosphorylation state, enabling researchers to investigate TRF2’s dynamic regulation in response to DNA damage, replication stress, or oncogenic signaling. It is widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to explore TRF2’s role in aging, cancer biology, and therapeutic resistance. Validation of this antibody typically includes testing in knockout models or phosphorylation-deficient mutants to ensure specificity.