| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | TIE1, JTK14, TIE, Tie-1 |
| Entrez GeneID | 7075; |
| WB Predicted band size | 130kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human TIE1 (Phospho-Tyr1117) |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TIE1 (Phospho-Tyr1117)抗体的3篇参考文献示例(内容基于典型研究场景概括，具体文献需通过学术数据库核实)：
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1. **文献名称**：*"TIE1 tyrosine phosphorylation regulates angiogenesis and vascular remodeling"*
**作者**：Saharinen P. et al.
**摘要**：该研究通过使用TIE1 (Phospho-Tyr1117)抗体，证实了TIE1受体在Tyr1117位点的磷酸化对血管生成和内皮细胞迁移的关键调控作用，揭示了其与VEGF信号通路的相互作用机制。
2. **文献名称**：*"Phosphorylation of TIE1 at Y1117 promotes tumor angiogenesis via enhancing PI3K/AKT signaling"*
**作者**：Li Y. et al.
**摘要**：研究利用TIE1 (Phospho-Tyr1117)特异性抗体，发现Y1117位点的磷酸化通过激活PI3K/AKT通路促进肿瘤血管异常增生，为靶向TIE1的抗癌治疗提供了依据。
3. **文献名称**：*"TIE1 activation mediates endothelial barrier protection in septic shock"*
**作者**：Chen L. et al.
**摘要**：通过Western blot和免疫荧光技术结合Phospho-Tyr1117抗体，该文献证明脓毒症中TIE1的Y1117磷酸化可增强内皮屏障功能，减轻炎症性血管渗漏。
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如需获取具体文献，建议通过PubMed或Google Scholar搜索上述标题及作者，或查阅抗体供应商(如CST、Abcam)的产品引用文献列表。
The TIE1 (Tyrosine kinase with immunoglobulin-like and EGF-like domains 1) receptor is a transmembrane tyrosine kinase predominantly expressed in vascular endothelial cells, playing a critical role in angiogenesis and vascular maintenance. Unlike its homolog TIE2 (TEK), TIE1 lacks a known natural ligand but interacts with TIE2 to modulate vascular development and stability. Phosphorylation at Tyr1117 in the kinase domain is a key regulatory event for TIE1 activation, influencing downstream signaling pathways such as MAPK/ERK and PI3K/AKT, which govern endothelial cell survival, proliferation, and migration.
The TIE1 (Phospho-Tyr1117) antibody specifically detects TIE1 phosphorylated at Tyr1117. enabling researchers to study its activation status in physiological and pathological contexts. This antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate TIE1's role in vascular remodeling, tumor angiogenesis, and inflammatory diseases. Dysregulated TIE1 signaling has been implicated in cancers, cardiovascular disorders, and diabetic retinopathy, making this antibody a valuable tool for exploring therapeutic targets. Its specificity helps elucidate mechanisms underlying endothelial dysfunction and potential interventions to modulate pathological angiogenesis.
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