Cat: PA2000-4370

Recombinant Human CXCL6 Protein,His

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关键信息

  • 基因名

    CXCL6

  • 应用

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    CXCL6;GCP2;SCYB6;C-X-C motif chemokine 6

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    His tag N-Terminus

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    P80162

  • 表达区间

    43-114aa

  • 氨基酸序列

    VLTELRCTCL RVTLRVNPKT IGKLQVFPAG PQCSKVEVVA SLKNGKQVCL DPEAPFLKKV IQKILDSGNK KN

  • 分子量

    7.9 kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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背景信息

CXCL6, also known as CXC chemokine ligand 6 or Gro-α, is a member of the CXC chemokine family that plays a crucial role in the immune response and inflammation. It is primarily produced by various cell types, including macrophages, fibroblasts, and endothelial cells, in response to pro-inflammatory stimuli. CXCL6 exhibits potent chemotactic properties, attracting neutrophils and other immune cells to sites of tissue injury or infection, thus participating in host defense mechanisms. Research has shown that CXCL6 is involved in various pathological conditions, including cancer, autoimmune diseases, and chronic inflammatory disorders. Its expression levels are often elevated in tumors, where it contributes to tumor progression, metastasis, and the creation of an immunosuppressive microenvironment. To further understand its biologic functions and therapeutic potential, the development of recombinant CXCL6 protein for in vitro and in vivo studies has gained significant interest. This recombinant protein can be used to explore the mechanisms by which CXCL6 influences immune cell behavior, its role in disease processes, and potential applications in targeted therapies. Understanding CXCL6's interactions and signaling pathways could pave the way for novel therapeutic strategies aimed at modulating immune responses and improving outcomes in diseases characterized by dysregulated inflammation or immune evasion.

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