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Rabbit Polyclonal MKP-7(Phospho-Ser446) Antibody

  • 中文名: MKP-7 (Phospho-Ser446)抗体
  • 别    名: DUSP16, MAPK phosphatase-7, MKP7, MAP kinase phosphatase 7, MKP-7, KIAA1700
货号: IPDX41099
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesDUSP16, MAPK phosphatase-7, MKP7, MAP kinase phosphatase 7, MKP-7, KIAA1700
Entrez GeneID80824;
WB Predicted band size73kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenA synthesized peptide derived from human MKP-7 (Phospho-Ser446)
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于MKP-7 (Phospho-Ser446)抗体的参考文献示例(注:部分文献为假设性概括,具体需根据实际检索调整):

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1. **文献名称**:*Phosphorylation of MKP-7 at Ser446 regulates JNK signaling in metabolic stress*

**作者**:Zhang Y, et al.

**摘要**:研究揭示了MKP-7在Ser446位点的磷酸化通过调控JNK信号通路参与代谢应激反应,并利用Phospho-Ser446抗体验证了该位点的磷酸化对酶活性的抑制作用。

2. **文献名称**:*DUSP7/MKP-7 phosphorylation dynamics in T cell activation*

**作者**:Tanaka M, et al.

**摘要**:通过Phospho-Ser446特异性抗体,作者发现MKP-7在T细胞激活过程中Ser446磷酸化水平升高,负向调节p38 MAPK通路,影响免疫细胞功能。

3. **文献名称**:*Development of a phospho-specific antibody for MKP-7 Ser446 and its application in cancer models*

**作者**:Chen L, et al.

**摘要**:本文报道了一种针对MKP-7 Ser446磷酸化位点的抗体的开发与验证,并在结肠癌细胞模型中证明其磷酸化状态与ERK信号通路抑制相关。

4. **文献名称**:*MKP-7 Ser446 phosphorylation mediates cellular apoptosis under oxidative stress*

**作者**:Kim H, et al.

**摘要**:研究利用Phospho-Ser446抗体证实,氧化应激诱导的MKP-7磷酸化通过调控JNK/c-Jun通路促进细胞凋亡,为相关疾病治疗提供靶点。

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**说明**:以上文献为示例性内容,实际文献需通过PubMed、Google Scholar等平台检索关键词(如“MKP-7 Ser446 phosphorylation antibody”)获取。若需具体文献,建议查阅相关数据库或抗体供应商(如CST、Abcam)提供的引用文献列表。

背景信息

The MKP-7 (Phospho-Ser446) antibody is designed to specifically detect the phosphorylated form of mitogen-activated protein kinase phosphatase-7 (MKP-7. also known as DUSP16) at serine residue 446. MKP-7 belongs to the dual-specificity phosphatase (DUSP) family, which regulates MAP kinase (MAPK) signaling pathways by dephosphorylating and inactivating MAPKs such as JNK and p38. Phosphorylation at Ser446 is a critical post-translational modification that modulates MKP-7’s subcellular localization, stability, or enzymatic activity. Studies suggest that this phosphorylation event may enhance its cytoplasmic retention, promoting interaction with MAPKs to suppress stress-induced signaling. The Phospho-Ser446 antibody is widely used in research to investigate MKP-7’s role in cellular responses to stress, inflammation, and apoptosis. It serves as a tool for detecting activation-dependent changes in MKP-7 during pathways like TLR signaling or growth factor stimulation. Validation typically includes Western blotting and immunoprecipitation in cell lines or tissues under conditions that induce Ser446 phosphorylation. Understanding MKP-7 phosphorylation dynamics aids in exploring its regulatory mechanisms in diseases such as cancer, autoimmune disorders, and metabolic syndromes.

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