| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | NDRG2, KIAA1248, N-myc downstream regulator 2, NDRG family member 2, SYLD, NDR1-related protein NDR2, Protein Syld709613, Syld709613 protein, Cytoplasmic protein Ndr1, Protein NDRG2 |
| Entrez GeneID | 57447; |
| WB Predicted band size | 41kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human NDRG2 (Phospho-Thr348) |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于NDRG2 (Phospho-Thr348)抗体的3篇参考文献的简要总结：
1. **文献名称**: *NDRG2 Phosphorylation at Thr348 Promotes Tumor Metastasis via Extracellular Vesicle-Mediated Communication*
**作者**: Li X, et al.
**摘要**: 研究揭示了NDRG2在Thr348位点的磷酸化通过调控细胞外囊泡释放促进肿瘤转移，该抗体用于检测磷酸化NDRG2在肿瘤组织中的表达水平及其与临床预后的相关性。
2. **文献名称**: *Phosphorylation of NDRG2 at Thr348 Modulates Neuronal Apoptosis in Cerebral Ischemia*
**作者**: Wang Y, et al.
**摘要**: 文章发现脑缺血中NDRG2的Thr348磷酸化通过激活JNK通路加剧神经元凋亡，研究使用该抗体通过免疫印迹和免疫荧光验证磷酸化NDRG2在缺血模型中的动态变化。
3. **文献名称**: *AMPK-dependent Phosphorylation of NDRG2 at Thr348 Suppresses Hepatic Lipogenesis*
**作者**: Chen L, et al.
**摘要**: 该研究证明AMPK介导的NDRG2 Thr348磷酸化抑制肝脏脂质合成，抗体被用于小鼠肝组织样本中磷酸化NDRG2的功能分析，并关联其与代谢综合征的关系。
**备注**：以上文献为示例，实际引用需根据具体研究补充。建议通过PubMed或Google Scholar以关键词“NDRG2 Phospho-Thr348”或抗体编号(如CST #XXXX)检索最新文献。
The NDRG2 (Phospho-Thr348) antibody is a specialized tool used to detect the phosphorylation of threonine 348 (Thr348) in the N-myc downstream-regulated gene 2 (NDRG2) protein. NDRG2 belongs to the NDRG family, which plays roles in cell differentiation, stress responses, and tumor suppression. Phosphorylation at Thr348 is a critical post-translational modification regulating NDRG2's activity, stability, or interactions with other proteins. This modification is often linked to signaling pathways involving kinases such as AMP-activated protein kinase (AMPK) or glycogen synthase kinase 3β (GSK3β), which modulate NDRG2's function in cellular processes like proliferation, apoptosis, and metabolism.
The antibody is typically validated for applications like Western blotting, immunohistochemistry (IHC), or immunofluorescence (IF) to study NDRG2 phosphorylation status in biological samples. Researchers use it to explore NDRG2's role in diseases, particularly cancer, where NDRG2 may act as a tumor suppressor, and neurological disorders, given its expression in brain tissues. Specificity is confirmed using controls like phosphorylation-deficient mutants or phosphatase-treated lysates.
Understanding NDRG2 phosphorylation at Thr348 provides insights into its regulatory mechanisms and potential as a therapeutic target or biomarker. This antibody is crucial for dissecting context-dependent NDRG2 behavior in both physiological and pathological conditions.
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