Rabbit Polyclonal HNRPA(Phospho-Ser84) Antibody

The HNRPA (Phospho-Ser84) antibody is a specialized tool used to detect the phosphorylation of heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) at serine residue 84. hnRNP A1 is a key RNA-binding protein involved in mRNA processing, splicing, transport, and stability. Phosphorylation at Ser84 is a post-translational modification that regulates hnRNP A1's function, particularly under cellular stress. For example, during the DNA damage response or oxidative stress, phosphorylation at this site modulates hnRNP A1's nucleocytoplasmic shuttling, influencing its role in mRNA metabolism or stress granule formation. This modification is often mediated by kinases such as AMP-activated protein kinase (AMPK) or Aurora B, depending on the cellular context. The HNRPA (Phospho-Ser84) antibody is widely used in research to study stress-responsive pathways, neurodegenerative diseases (e.g., ALS), or cancer, where hnRNP A1 dysregulation is implicated. Its applications include Western blotting, immunofluorescence, and immunoprecipitation to assess phosphorylation dynamics in experimental models. Validated specificity for the phosphorylated epitope ensures reliable detection, making it critical for investigating RNA-protein interactions and stress-related signaling mechanisms.