Rabbit Polyclonal ROR2(Phospho-Ser449) Antibody

The ROR2 (Phospho-Ser449) antibody is designed to detect the phosphorylated form of Receptor Tyrosine Kinase-like Orphan Receptor 2 (ROR2) at serine residue 449. ROR2. a member of the ROR family of transmembrane receptors, plays critical roles in developmental processes, including skeletal formation, neuronal migration, and cell polarity, primarily through its involvement in non-canonical Wnt signaling pathways (e.g., Wnt5a-mediated signaling). Phosphorylation at Ser449. located within the intracellular domain of ROR2. is associated with receptor activation and downstream signaling modulation. This post-translational modification may regulate interactions with adaptor proteins or influence receptor trafficking, though its precise mechanistic role remains under investigation. Dysregulation of ROR2 signaling has been implicated in cancers (e.g., melanoma, osteosarcoma) and developmental disorders like Robinow syndrome. The ROR2 (Phospho-Ser449) antibody serves as a tool to study the activation status of ROR2 in cellular models, enabling researchers to explore its phosphorylation dynamics in response to stimuli, disease progression, or therapeutic interventions. Validation typically includes testing in knockout cell lines or phosphorylation-blocking mutants to ensure specificity. Applications span Western blotting, immunohistochemistry, and immunofluorescence, supporting both basic research and translational studies targeting ROR2-related pathways.