Rabbit Polyclonal EPHB4(Phospho-Tyr987) Antibody

The EPHB4 (Phospho-Tyr987) antibody is a specialized tool used to detect the phosphorylated form of tyrosine residue 987 (Y987) on the EPHB4 receptor, a member of the Eph receptor tyrosine kinase family. EPHB4 plays critical roles in cell-cell communication, vascular development, and tissue patterning by interacting with membrane-bound ephrin ligands. Phosphorylation at Y987 is a key regulatory event triggered by receptor activation, often through ligand binding or autophosphorylation. This post-translational modification modulates downstream signaling pathways involved in cell migration, adhesion, and angiogenesis. Dysregulation of EPHB4 signaling has been implicated in cancers, vascular malformations, and other pathologies. The Phospho-Tyr987 antibody enables researchers to study EPHB4 activation status, aiding investigations into its physiological and pathological roles. It is commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess phosphorylation-dependent interactions or signaling dynamics. Studies utilizing this antibody have contributed to understanding EPHB4's dual role in tumor progression—acting as both an oncogene and tumor suppressor depending on context—and its potential as a therapeutic target. Proper validation, including knockout controls and peptide competition assays, is essential to confirm antibody specificity.