Rabbit Polyclonal EPHA6(Phospho-Tyr977) Antibody

The EPHA6 (Phospho-Tyr977) antibody is designed to detect the phosphorylation of tyrosine residue 977 in the Ephrin type-A receptor 6 (EPHA6), a member of the Eph receptor tyrosine kinase family. Eph receptors play critical roles in cell-cell communication, particularly during developmental processes such as axon guidance, tissue patterning, and cell migration. EPHA6 is involved in regulating synaptic plasticity, neuronal connectivity, and tumor progression. Phosphorylation at specific tyrosine residues, including Tyr977. is a key regulatory mechanism for Eph receptor activation. Upon ligand binding (ephrins), Eph receptors undergo autophosphorylation, initiating downstream signaling cascades that modulate cytoskeletal dynamics, adhesion, and gene expression. The EPHA6 (Phospho-Tyr977) antibody specifically recognizes the phosphorylated form of Tyr977. enabling researchers to study EPHA6 activation status in various contexts. This antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate EPHA6's role in neurological disorders, cancer metastasis, and developmental biology. Its specificity makes it a valuable tool for understanding Ephrin signaling pathways and exploring therapeutic targets for diseases linked to dysregulated Eph receptor activity.