| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ERBB4, ERBB 4, HER4, p180 erb4, p180erbB4 |
| Entrez GeneID | 2066; |
| WB Predicted band size | 180kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human HER4 (Phospho-Tyr1242) |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于HER4 (Phospho-Tyr1242)抗体的3篇示例文献(内容为假设性概括，实际文献需通过数据库验证)：
1. **文献名称**：*Phosphorylation of HER4 at Tyr1242 promotes tumor cell invasion in breast cancer*
**作者**：Smith A, et al.
**摘要**：研究证实HER4在Tyr1242位点的磷酸化通过激活MAPK/ERK通路增强乳腺癌细胞侵袭能力，使用Phospho-Tyr1242抗体验证了磷酸化水平与临床预后的相关性。
2. **文献名称**：*HER4 activation and phosphorylation status in lung adenocarcinoma: Implications for targeted therapy*
**作者**：Chen L, et al.
**摘要**：利用Phospho-Tyr1242特异性抗体分析肺癌组织中HER4活性，发现该位点磷酸化与EGFR突变协同促进肿瘤生长，提示其作为联合治疗靶点的潜力。
3. **文献名称**：*Characterization of a monoclonal antibody specific for HER4 phosphorylated at Tyr1242*
**作者**：Wang Y, et al.
**摘要**：报道了一种高特异性的抗HER4 (Phospho-Tyr1242)单克隆抗体的开发，验证了其在Western blot和免疫荧光中的灵敏度和特异性，并用于检测多种癌细胞系中的激活态HER4.
如需真实文献，建议通过PubMed或Google Scholar检索关键词“HER4 Phospho-Tyr1242 antibody”或“ERBB4 Y1242 phosphorylation”。
The HER4 (Phospho-Tyr1242) antibody detects the activated form of HER4 (ErbB4), a receptor tyrosine kinase belonging to the EGFR/ERBB family. HER4 plays critical roles in cell proliferation, differentiation, and survival by forming homodimers or heterodimers with other ERBB members upon ligand binding (e.g., neuregulins). Phosphorylation at tyrosine residue 1242 (Y1242) occurs during receptor activation, a key step in downstream signaling pathways such as PI3K/AKT and MAPK. This post-translational modification serves as a biomarker for HER4 activation, enabling researchers to study its involvement in physiological processes and diseases, including cancer, heart development, and neurodevelopmental disorders.
The HER4 (Phospho-Tyr1242) antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess HER4 activation status in cell lines, tissues, or tumor samples. Its specificity for the phosphorylated epitope ensures accurate detection of signaling activity, distinguishing active HER4 from its inactive form. Dysregulated HER4 signaling has been implicated in breast cancer, melanoma, and glioblastoma, making this antibody a valuable tool for both mechanistic studies and translational research. Validation parameters, such as knockout controls and peptide competition assays, are essential to confirm antibody specificity. Commercial sources often provide detailed validation data to support reproducibility across experimental models.
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