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Rabbit Polyclonal SRPK1(Phospho-Thr601) Antibody

  • 中文名: SRPK1 (Phospho-Thr601)抗体
  • 别    名: SRPK1, SFRS protein kinase 1, SFRSK1, SR-protein-specific kinase 1, SRSF protein kinase 1
货号: IPDX41159
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesOB; OBS; LEPD
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFull length fusion protein
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于SRPK1 (Phospho-Thr601)抗体的参考文献示例(注:以下内容为虚构示例,实际文献需通过学术数据库检索确认):

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1. **文献名称**: *Phosphorylation of SRPK1 at Thr601 regulates its kinase activity and subcellular localization in colorectal cancer*

**作者**: Zhang Y, et al.

**摘要**: 本研究揭示了SRPK1在结直肠癌中Thr601位点的磷酸化通过CDK1介导,促进其激酶活性并增强肿瘤侵袭性。通过使用Phospho-Thr601特异性抗体,作者发现该位点的磷酸化与患者预后不良相关。

2. **文献名称**: *Development and validation of a phospho-specific antibody targeting SRPK1 Thr601 for functional studies in mRNA splicing*

**作者**: Lee S, et al.

**摘要**: 该研究报道了一种针对SRPK1 Thr601磷酸化位点的多克隆抗体的开发,并通过免疫印迹和免疫荧光验证其特异性。实验表明,Thr601磷酸化调控SRPK1与剪接因子的相互作用。

3. **文献名称**: *CDK1-mediated phosphorylation of SRPK1 at Thr601 drives cell cycle-dependent alternative splicing*

**作者**: Wang H, et al.

**摘要**: 作者发现CDK1在G2/M期磷酸化SRPK1 Thr601.导致其向核内转位并激活下游剪接因子(如SRSF1)。研究利用Phospho-Thr601抗体证明该修饰对细胞周期进程至关重要。

4. **文献名称**: *Dynamic phosphorylation of SRPK1 at Thr601 under oxidative stress modulates neuronal survival*

**作者**: Chen L, et al.

**摘要**: 通过Phospho-Thr601抗体的应用,本研究揭示了氧化应激下SRPK1 Thr601的动态磷酸化通过调节Bcl-x剪接异构体平衡影响神经元存活,为神经退行性疾病提供了潜在机制。

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**注意**:以上文献为示例,实际引用需通过PubMed、Google Scholar等平台以关键词“SRPK1 Phospho-Thr601”或“SRPK1 Thr601 phosphorylation”检索真实文献。部分抗体厂商(如Cell Signaling Technology)的产品手册也可能提供相关参考文献。

背景信息

The SRPK1 (Phospho-Thr601) antibody is designed to detect the phosphorylation of serine/arginine-rich protein-specific kinase 1 (SRPK1) at threonine 601. a post-translational modification critical for regulating its activity and function. SRPK1 is a serine-threonine kinase involved in pre-mRNA splicing by phosphorylating serine-arginine (SR) repeat domains in splicing factors, such as SRSF proteins, influencing their subcellular localization and interaction with spliceosomes. Phosphorylation at Thr601 is associated with SRPK1’s kinase activity modulation, potentially affecting its substrate specificity, enzymatic efficiency, or binding to regulatory partners. Dysregulation of SRPK1 is linked to diseases like cancer, where aberrant splicing contributes to tumor progression, and neurological disorders. This antibody serves as a key tool in studying SRPK1’s role in cellular processes, including splicing regulation, signal transduction, and stress responses. It is widely used in techniques like Western blotting, immunofluorescence, or immunohistochemistry to assess phosphorylation-dependent SRPK1 activation in various experimental models. Understanding Thr601 phosphorylation dynamics provides insights into SRPK1-related pathways and therapeutic targeting in pathologies marked by splicing dysregulation.

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