Rabbit Polyclonal ROR1(Phospho-Tyr786) Antibody

The ROR1 (Phospho-Tyr786) antibody is designed to detect the phosphorylated form of the receptor tyrosine kinase ROR1 (Receptor Tyrosine Kinase-Like Orphan Receptor 1) at tyrosine residue 786. ROR1 plays critical roles in embryonic development, particularly in neurite growth, cell migration, and organogenesis. In healthy adults, ROR1 expression is typically low or absent, but it is re-expressed in various cancers, including chronic lymphocytic leukemia (CLL), breast cancer, lung cancer, and pancreatic cancer, where it promotes tumor survival, proliferation, and metastasis. Phosphorylation at Tyr786 is associated with ROR1 activation and downstream signaling, often mediated by interactions with Wnt ligands or other kinases. This post-translational modification may regulate ROR1’s ability to recruit adaptor proteins or activate pathways like PI3K/AKT, MAPK/ERK, or NF-κB, contributing to oncogenic signaling. The ROR1 (Phospho-Tyr786) antibody is widely used in research to study ROR1 activation status in cancer models, evaluate therapeutic responses, or investigate mechanisms of ROR1-targeted therapies (e.g., monoclonal antibodies, CAR-T cells). Its specificity for the phosphorylated epitope makes it a valuable tool for distinguishing active ROR1 from its inactive form, aiding in biomarker studies and drug development efforts. Validation often includes Western blotting, immunohistochemistry, and flow cytometry using cell lines or tissues with confirmed ROR1 phosphorylation.