Rabbit Polyclonal c-Jun(Ab-73) Antibody

The c-Jun (Ab-73) antibody specifically targets the phosphorylated form of the c-Jun protein at serine 73 (Ser73), a key post-translational modification regulating its transcriptional activity. c-Jun, a component of the AP-1 transcription factor family, plays a critical role in cellular processes such as proliferation, differentiation, apoptosis, and stress responses. Activation of c-Jun occurs through phosphorylation by upstream kinases, including JNK (c-Jun N-terminal kinase), particularly in response to extracellular signals like cytokines, growth factors, or stressors. Phosphorylation at Ser73 enhances c-Jun’s transcriptional activity by promoting interactions with coactivators and stabilizing its DNA-binding ability. The c-Jun (Ab-73) antibody is widely used in research to study pathways involving AP-1 signaling, such as oncogenesis, inflammation, and cellular adaptation to stress. It is commonly applied in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect phosphorylated c-Jun in cell lines, tissues, or experimental models. Validated for specificity, this antibody helps elucidate mechanisms underlying diseases like cancer, neurodegenerative disorders, and immune dysregulation, where dysregulated AP-1 activity is implicated. Its utility in distinguishing activated c-Jun from its unphosphorylated form makes it a valuable tool for probing dynamic signaling events in both physiological and pathological contexts.