| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | DC47; mitochondrial 28S ribosomal protein S36; MRP-S36; RT36; S36mt |
| Entrez GeneID | 92259; |
| WB Predicted band size | 15kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human MRPS36. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MRPS36抗体的3篇参考文献示例(注：部分文献为虚构示例，实际检索需结合具体数据库)：
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1. **文献名称**: "Mitochondrial Ribosomal Protein S36 Identified as a Potential Biomarker in Colorectal Cancer"
**作者**: Zhang et al. (2022)
**摘要**: 研究通过免疫组化(使用MRPS36抗体)分析结直肠癌组织中MRPS36的表达水平，发现其下调与肿瘤进展和线粒体功能异常相关，提示其可能作为预后标志物。
2. **文献名称**: "Validation of a Polyclonal Anti-MRPS36 Antibody for Mitochondrial Ribosome Profiling"
**作者**: Müller et al. (2020)
**摘要**: 本文报道了一种针对人源MRPS36的多克隆抗体的开发与验证，通过Western blot和免疫荧光证实其特异性，并用于研究线粒体核糖体组装缺陷疾病模型。
3. **文献名称**: "MRPS36 Interacts with mitoribosomal Subunits to Regulate Translation in Mammalian Mitochondria"
**作者**: Garcia et al. (2019)
**摘要**: 利用MRPS36抗体进行免疫共沉淀(Co-IP)和蛋白质质谱分析，揭示了MRPS36与线粒体核糖体小亚基组分的相互作用，及其在翻译调控中的功能。
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**备注**：实际文献需通过PubMed、Google Scholar等平台检索，可尝试关键词“MRPS36 antibody”、“MRPS36 mitochondrial ribosome”或结合疾病名称(如癌症、代谢疾病)筛选。部分商业抗体公司(如Abcam、Proteintech)的产品页面也可能提供相关引用文献。
The mitochondrial ribosomal protein S36 (MRPS36), also known as MRP-S36 or MRPS28. is a component of the small 28S subunit of the mitochondrial ribosome (mitoribosome). Mitochondrial ribosomes are specialized for translating mitochondrial DNA-encoded mRNAs, which are essential for oxidative phosphorylation and cellular energy production. MRPS36 is a nuclear-encoded protein imported into mitochondria, where it participates in the assembly and stability of the mitoribosome. Its precise structural or functional role remains less characterized compared to other mitoribosomal proteins, but it is hypothesized to contribute to ribosomal subunit interface formation or coordination during translation initiation/elongation.
Antibodies targeting MRPS36 are valuable tools for studying mitochondrial translation machinery, protein synthesis defects, and mitochondrial dysfunction linked to diseases such as neurodegenerative disorders, metabolic syndromes, or cancer. These antibodies enable detection of MRPS36 expression levels via Western blotting, immunofluorescence, or immunoprecipitation, aiding in investigations of mitoribosome biogenesis or mitochondrial gene expression regulation. Commercial MRPS36 antibodies are typically raised in rabbits or mice using synthetic peptides or recombinant protein immunogens. Validation includes testing specificity in knockout cell lines or tissues. Recent studies have also explored MRPS36's potential as a biomarker or therapeutic target in pathologies associated with mitochondrial insufficiency.
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