关键信息
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基因名
Ptger2
- 应用
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别名
Ptger2；PTGER2；Prostaglandin E2 receptor EP4 subtype
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P35408
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表达区间
1-488aa
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氨基酸序列
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
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分子量
53.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
The research on Ptger2 recombinant protein has garnered significant attention due to the critical role of the prostaglandin E2 (PGE2) signaling pathway in various physiological and pathological processes. Ptger2, or the prostaglandin E receptor 2, is one of the four receptors for PGE2 and is involved in mediating its diverse effects, which include inflammatory responses, pain modulation, and regulation of immune functions. Dysregulation of the Ptger2 signaling pathway has been implicated in several conditions, such as cancer, cardiovascular diseases, and neurodegenerative disorders. The production of Ptger2 recombinant protein allows for detailed studies on its structure, function, and interactions with ligands. This research provides insights into the receptor's signaling mechanisms and aids in identifying potential therapeutic targets for modulating PGE2-related pathways. Additionally, recombinant Ptger2 protein can be utilized in drug discovery efforts, where small molecules or antibodies can be screened for their efficacy in modulating receptor activity. Understanding the biological role of Ptger2 through recombinant technology is essential for elucidating its contributions to health and disease, paving the way for novel therapeutic strategies.
