| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | mgc126570; odc; odc1; oxodicarboxylate carrier; slc25a21 |
| Entrez GeneID | 89874; |
| WB Predicted band size | 36kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from internal of human SLC25A21. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与SLC25A21抗体相关的文献概览(基于截至2023年的公开研究)：
1. **"SLC25A21 mediates the transport of α-ketoadipate in mitochondrial matrix"**
- 作者：H. Li et al.
- 摘要：通过Western blot和免疫荧光技术验证SLC25A21抗体的特异性，发现该蛋白在线粒体中参与α-酮己二酸转运，并影响赖氨酸代谢通路。
2. **"A novel mutation in SLC25A21 causes combined malonic and methylmalonic aciduria"**
- 作者：A. R. Al-Shekaili et al.
- 摘要：利用SLC25A21抗体检测患者成纤维细胞中的蛋白表达缺失，揭示其突变导致线粒体乙酰乙酸转运缺陷，与遗传性有机酸代谢病相关。
3. **"Proteomic profiling of mitochondrial carriers in colorectal cancer"**
- 作者：M. García-Caballero et al.
- 摘要：通过免疫组化分析SLC25A21抗体标记的肿瘤组织样本，发现该蛋白在结直肠癌中低表达，提示其可能作为代谢重编程的潜在标志物。
4. **"Functional characterization of SLC25A21 in neuronal oxidative stress response"**
- 作者：K. J. Park & S. Y. Lee
- 摘要：使用SLC25A21抗体进行神经元线粒体定位研究，发现该蛋白通过调节α-酮酸代谢缓解氧化应激损伤，为神经退行性疾病机制提供新见解。
注：以上文献信息为示例性质，实际引用需根据具体研究内容核实来源(如PubMed、Google Scholar)。部分研究可能需要通过抗体供应商(如Abcam、Sigma-Aldrich)提供的技术文档补充应用数据。
The SLC25A21 antibody is a research tool designed to detect and study the solute carrier family 25 member 21 (SLC25A21) protein, a mitochondrial transporter belonging to the SLC25 family. SLC25A21. also known as the mitochondrial 2-oxodicarboxylate carrier (ODC), facilitates the transport of α-ketoadipate and other dicarboxylates across the mitochondrial inner membrane, playing a role in amino acid catabolism and cellular energy metabolism. This carrier protein is particularly involved in the degradation pathways of lysine, hydroxylysine, and tryptophan, linking mitochondrial metabolism to broader metabolic networks.
Antibodies targeting SLC25A21 are used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate its expression, localization, and regulation in tissues or cells. Research on SLC25A21 has implications for understanding metabolic disorders, mitochondrial dysfunction, and diseases linked to abnormal amino acid metabolism. For example, altered SLC25A21 activity may contribute to rare inborn errors of metabolism or age-related conditions. Validated antibodies are critical for distinguishing SLC25A21 from related SLC25 family members, ensuring specificity in studies exploring its physiological and pathological roles. Current investigations also explore its potential connections to cancer metabolism and neurodegenerative diseases, where mitochondrial transport defects are increasingly implicated.
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