| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SHIK; SgK495 |
| Entrez GeneID | 83931; |
| WB Predicted band size | 49kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于STK4抗体的3篇参考文献及其摘要内容的简要概括：
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1. **文献名称**：*"The Hippo pathway effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies"*
**作者**：Lin L. et al.
**摘要**：该研究利用STK4(MST1)抗体通过Western blot分析Hippo通路中STK4的表达水平，发现STK4缺失导致YAP蛋白激活，进而增强癌细胞对RAF/MEK抑制剂的耐药性。抗体用于验证基因敲除模型中的蛋白表达变化。
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2. **文献名称**：*"MST1/STK4 suppresses colorectal cancer through antagonizing oncogenic RAS signaling"*
**作者**：Zhou D. et al.
**摘要**：作者使用STK4特异性抗体检测结直肠癌组织中STK4蛋白的表达，发现其低表达与RAS信号通路过度激活相关。实验通过免疫组化(IHC)和免疫沉淀(IP)验证STK4在抑制肿瘤生长中的作用。
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3. **文献名称**：*"Regulation of neuronal survival by the serine-threonine protein kinase MST1"*
**作者**：Katagiri K. et al.
**摘要**：研究通过STK4抗体在小鼠脑组织中的免疫荧光染色，揭示STK4通过调控caspase级联反应参与神经元凋亡过程。抗体特异性验证显示其在神经退行性疾病模型中的关键作用。
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**备注**：上述文献为示例，实际引用需根据具体实验场景核对原文。若需全文信息，可通过PubMed或期刊数据库检索标题及作者。
The STK4 antibody targets the serine/threonine kinase 4 (STK4), also known as mammalian STE20-like kinase 1 (MST1), a key component of the Hippo signaling pathway. STK4/MST1 regulates cellular processes such as apoptosis, proliferation, and immune cell function by phosphorylating downstream effectors like LATS1/2. It plays a critical role in maintaining tissue homeostasis, organ size, and immune system regulation, particularly in T-cell development and function. Dysregulation of STK4 is linked to cancers, autoimmune disorders, and primary immunodeficiency diseases.
STK4 antibodies are widely used in research to study protein expression, localization, and activation through techniques like Western blotting, immunohistochemistry, and flow cytometry. These antibodies help identify STK4's involvement in tumor suppression, its interaction with regulatory proteins (e.g., RASSF1), and its role in stress-induced apoptosis. Mutations or deletions in the STK4 gene are associated with conditions like combined immunodeficiency and lymphoproliferative syndromes, making these antibodies vital for diagnostic and therapeutic research. Commercial STK4 antibodies are typically developed in hosts like rabbits or mice, with validation across multiple applications to ensure specificity.
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