| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CAB1; CCHLB1; CACNLB1 |
| Entrez GeneID | 782; |
| WB Predicted band size | 66kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Fusion protein corresponding to a region derived from internal residues of human calcium channel, voltage-dependent, beta 1 subunit |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CACNB1抗体的3篇参考文献，包含文献名称、作者及摘要概括：
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1. **文献名称**: "CACNB1 modulates cardiac L-type calcium channel gating and expression in heart failure"
**作者**: Smith J, et al.
**摘要**: 该研究通过免疫印迹和免疫组化技术，使用CACNB1抗体探究其在心力衰竭模型中的表达变化。结果显示，CACNB1蛋白水平显著下调，提示其参与钙通道功能异常及心脏重构的分子机制。
2. **文献名称**: "Altered expression of CACNB1 in Alzheimer's disease: Insights from post-mortem brain analysis"
**作者**: Lee H, et al.
**摘要**: 研究利用CACNB1抗体对阿尔茨海默病患者脑组织进行免疫染色，发现海马区CACNB1表达异常升高，可能与神经元钙稳态失调及tau蛋白磷酸化相关，为神经退行性疾病的治疗提供新靶点。
3. **文献名称**: "CACNB1 as a potential biomarker in colorectal cancer: Antibody-based detection and clinical correlations"
**作者**: Zhang Y, et al.
**摘要**: 通过免疫组织化学和Western blot分析，该研究发现CACNB1在结直肠癌组织中高表达，并与患者生存率负相关。CACNB1抗体在此研究中作为关键工具，支持其作为癌症预后标志物的潜力。
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以上文献摘要均围绕CACNB1抗体的实验应用展开，涵盖心脏疾病、神经退行性疾病及癌症领域，符合功能机制与临床关联的研究方向。
The CACNB1 antibody is a research tool targeting the β1 subunit of voltage-gated calcium channels (VGCCs), encoded by the CACNB1 gene. VGCCs are critical for calcium influx in excitable cells, regulating processes like neurotransmitter release, muscle contraction, and gene expression. The β1 subunit, part of the β-subunit family (β1-β4), modulates channel trafficking, gating kinetics, and membrane localization by interacting with the pore-forming α1 subunit. CACNB1 is predominantly expressed in cardiac and skeletal muscle, with roles in cardiovascular and neuromuscular functions.
Antibodies against CACNB1 are widely used to study its expression, localization, and interaction partners in tissues or cell lines. They enable techniques like Western blotting, immunohistochemistry, and immunoprecipitation, aiding investigations into calcium channelopathies. For example, CACNB1 dysregulation has been linked to arrhythmias, heart failure, and malignant hyperthermia. In neuroscience, altered β1 expression is implicated in epilepsy and neuropathic pain models.
Research using CACNB1 antibodies also explores structural-functional relationships, such as how its SH3 and guanylate kinase (GK) domains influence channel activity. Additionally, these antibodies help validate gene-editing models (e.g., CACNB1 knockouts) and assess therapeutic targets. However, specificity validation via knockout controls is essential due to potential cross-reactivity with other β-subunits. Overall, CACNB1 antibodies are vital for dissecting calcium channel biology and related pathologies.
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