Recombinant Human CDH6 protein

中文名： 钙粘蛋白6(CDH6)重组蛋白
别名： CDH6；Cadherin-6

货号: PA1000-6461

Price： ￥询价

20μg 50μg 100μg ＞100μg

数量：

大包装询价

产品详情

纯度	>95%SDS-PAGE.
种属	Human
靶点	CDH6
Uniprot No	P55285
内毒素	< 0.01EU/μg
表达宿主	E.coli
表达区间	22-615aa
氨基酸序列	TLSTPLSKRTSGFPAKKRALELSGNSKNELNRSKRSWMWNQFFLLEEYTG SDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDR EEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATV PEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIK TALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRF PQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMFDV ITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSA TVRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVK YSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQ SSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQTLHAVDKDDPY SGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLPV VISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEALIHPTGLSTGAVDH HHHHH
预测分子量	67 kDa
蛋白标签	His tag N-Terminus
缓冲液	PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
稳定性 & 储存条件	Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶	Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

参考文献

以下是关于CDH6重组蛋白的模拟参考文献示例(实际文献请通过学术数据库查询)：

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1. **文献名称**: *Recombinant CDH6 Protein Promotes Cell Migration in Ovarian Cancer Models*

**作者**: Zhang, L. et al.

**摘要**: 本研究通过大肠杆菌表达系统纯化CDH6重组蛋白，并发现其在卵巢癌细胞系中增强细胞迁移和侵袭能力。实验表明CDH6可能通过激活Wnt/β-catenin通路促进肿瘤转移。

2. **文献名称**: *Structural Characterization of Human CDH6 Extracellular Domain Using Cryo-EM*

**作者**: Smith, J.R. & Kumar, S.

**摘要**: 利用冷冻电镜解析了CDH6胞外域重组蛋白的三维结构，揭示了其独特的钙离子结合位点，为设计靶向CDH6的抑制剂提供了结构基础。

3. **文献名称**: *CDH6 Recombinant Protein as a Biomarker for Renal Cell Carcinoma*

**作者**: Tanaka, M. et al.

**摘要**: 通过哺乳动物细胞表达系统制备高纯度CDH6重组蛋白，并验证其在肾细胞癌患者血清中的特异性高表达，提示其作为潜在诊断标志物的价值。

4. **文献名称**: *Functional Analysis of CDH6 in Zebrafish Embryogenesis*

**作者**: Chen, H. & Wei, Y.

**摘要**: 研究利用重组CDH6蛋白进行斑马鱼胚胎显微注射实验，证明CDH6在神经嵴细胞分化和胚胎组织形态发生中起关键作用。

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**注意**：以上文献为模拟内容，实际研究需查阅PubMed、Web of Science等平台获取。

背景信息

CDH6 recombinant protein is derived from human Cadherin-6 (CDH6), a member of the cadherin superfamily, which plays critical roles in cell-cell adhesion, tissue morphogenesis, and cellular signaling. CDH6. also known as K-cadherin, is a type I classical cadherin characterized by five extracellular cadherin (EC) domains, a transmembrane region, and a conserved cytoplasmic domain that interacts with catenins to regulate cytoskeletal dynamics. It is predominantly expressed during embryonic development, particularly in the kidney, thyroid, and nervous system, and exhibits tissue-specific expression patterns in adults.

In cancer biology, CDH6 has gained attention due to its aberrant overexpression in malignancies such as ovarian cancer, renal cell carcinoma, and thyroid tumors. Its dysregulation is linked to tumor progression, metastasis, and epithelial-mesenchymal transition (EMT), making it a potential therapeutic target or diagnostic biomarker. Recombinant CDH6 proteins are engineered to study these mechanisms, typically produced in mammalian or insect cell systems to ensure proper post-translational modifications, including glycosylation and calcium-dependent structural stability.

Research applications of CDH6 recombinant protein include ligand-receptor interaction studies, antibody development for diagnostic assays, and screening small-molecule inhibitors for targeted therapies. Its extracellular domain is often prioritized in recombinant designs to investigate homophilic/heterophilic binding or to generate antibodies for immunohistochemistry or liquid biopsy platforms. Recent studies also explore CDH6's role in cellular signaling pathways, such as Wnt/β-catenin and PI3K/AKT, revealing its cross-talk with oncogenic networks. As a recombinant tool, it bridges translational research in oncology and regenerative medicine, particularly in understanding tissue-specific adhesion defects. However, functional variability across isoforms and tumor types necessitates careful validation in experimental models.