| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ANKDD1A |
| Uniprot No | Q495B1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-522aa |
| 氨基酸序列 | MQEELAWETD GLLPLERQLH EAARQNNVGR MQELIGRRVN TRARNHVGRV ALHWAAGAGH EQAVRLLLEH EAAVDEEDAV GALTEARLCF GMNALLLSAW FGHLRILQIL VNSGAKIHCE SKDGLTLLHC AAQKGHVPVL AFIMEDLEDV ALDHVDKLGR TAFHRAAEHG QLDALDFLVG SGCDHNVKDK EGNTALHLAA GRGHMAVLQR LVDIGLDLEE QNAEGLTALH SAAGGSHPDC VQLLLRAGST VNALTQKNLS CLHYAALSGS EDVSRVLIHA GGCANVVDHQ GASPLHLAVR HNFPALVRLL INSDSDVNAV DNRQQTPLHL AAEHAWQDIA DMLLIAGVDL NLRDKQGKTA LAVAVRSNHV SLVDMIIKAD RFYRWEKDHP SDPSGKSLSF KQDHRQETQQ LRSVLWRLAS RYLQPREWKK LAYSWEFTEA HVDAIEQQWT GTRSYQEHGH RMLLIWLHGV ATAGENPSKA LFEGLVAIGR RDLAGWSTMA RSQLTATSAS RVQMILVPQP PE |
| 分子量 | 57.5 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于ANKDD1A的假设性参考文献示例(注：因该蛋白研究较少，以下内容为示例性概括，非真实文献)：
1. **文献名称**: ANKDD1A regulates apoptosis via death domain interactions
**作者**: Zhang L, et al.
**摘要**: 研究揭示ANKDD1A通过其死亡结构域与Caspase-8结合，促进线粒体依赖性细胞凋亡通路，可能成为癌症治疗的潜在靶点。
2. **文献名称**: Structural analysis of ANKDD1A in neurodegenerative disorders
**作者**: Gupta R, et al.
**摘要**: 通过质谱和分子建模发现ANKDD1A在阿尔茨海默病患者脑组织中的异常聚集，提示其与tau蛋白病理相关。
3. **文献名称**: ANKDD1A modulates Wnt/β-catenin signaling in colorectal cancer
**作者**: Wang X, et al.
**摘要**: 实验证明ANKDD1A通过锚蛋白重复序列与APC蛋白相互作用，抑制结直肠癌细胞增殖并增强5-FU化疗敏感性。
4. **文献名称**: Genome-wide association study implicates ANKDD1A in autoimmune diseases
**作者**: Kim S, et al.
**摘要**: 全基因组关联分析发现ANKDD1A基因多态性与类风湿关节炎显著相关，可能通过调控T细胞激活参与自身免疫反应。
**备注**：目前ANKDD1A的公开研究数据有限，建议通过PubMed或Web of Science检索最新文献。真实研究需以实验数据为准，上述示例仅供理解文献格式参考。
**Ankyrin Repeat and Death Domain-Containing Protein 1A (ANKDD1A)** is a human protein encoded by the *ANKDD1A* gene. Characterized by two conserved structural motifs—ankyrin repeats (ANK) and a death domain (DD)—it is hypothesized to participate in protein-protein interactions and cellular signaling pathways. Ankyrin repeats typically mediate binding to diverse partners, while the death domain is often associated with apoptotic or inflammatory signaling, suggesting roles in cell survival, proliferation, or immune response regulation.
ANKDD1A remains relatively understudied, but emerging evidence links it to cancer biology. Studies report its dysregulation in malignancies such as gastric, liver, and breast cancers, where reduced expression correlates with tumor progression and poor prognosis. Epigenetic silencing via promoter hypermethylation has been proposed as a mechanism for its downregulation, implying potential tumor-suppressive functions. Additionally, *ANKDD1A* variants are associated with neurodevelopmental disorders, hinting at broader physiological roles.
Despite these clues, the precise molecular mechanisms and signaling networks involving ANKDD1A remain unclear. Current research focuses on validating its interactions (e.g., with components of NF-κB or MAPK pathways) and exploring its utility as a biomarker or therapeutic target. Further functional studies are essential to unravel its contributions to disease pathogenesis and normal cellular processes.
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