关键信息
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基因名
MS4A2
- 应用
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别名
High affinity immunoglobulin epsilon receptor subunit beta. FcERI. Fc epsilon receptor I beta-chain. IgE Fc receptor subunit beta. Membrane-spanning 4-domains subfamily A member 2
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q01362
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表达区间
1-244 aa
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氨基酸序列
MDTESNRRANLALPQEPSSVPAFEVLEISPQEVSSGRLLKSASSPPLHTWLTVLKKEQEFLGVTQILTAMICLCFGTVVCSVLDISHIEGDIFSSFKAGYPFWGAIFFSISGMLSIISERRNATYLVRGSLGANTASSIAGGTGITILIINLKKSLAYIHIHSCQKFFETKCFMASFSTEIVVMMLFLTILGLGSAVSLTICGAGEELKGNKVPEDRVYEELNIYSATYSELEDPGEMSPPIDL
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分子量
52.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
MS4A2, a member of the MS4A (membrane-spanning 4-domains subfamily A) gene family, has garnered considerable attention in immunological research due to its potential role in various immune responses and disease processes. This protein is primarily expressed in B cells and is believed to be involved in the regulation of cell signaling pathways, contributing to B cell activation and differentiation. Its relevance has been highlighted in several studies linking MS4A2 to autoimmune disorders, such as multiple sclerosis and systemic lupus erythematosus, as variations in MS4A gene expression have been associated with altered immune responses. Furthermore, MS4A2 has been implicated in certain cancers, suggesting its involvement in tumor immunity and the tumor microenvironment. Given its significant biological functions and associations with various diseases, researchers are increasingly focusing on the characterization of recombinant MS4A2 proteins to investigate their structural properties, functional roles, and potential as therapeutic targets. The production of MS4A2 recombinant proteins allows for detailed studies of the protein's interactions, signaling mechanisms, and the effects of genetic variations. Overall, the investigation of MS4A2 offers promising insights into the complex interplay between the immune system and disease, thereby paving the way for novel diagnostic and therapeutic strategies.
