| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | AP3M2 |
| Uniprot No | P53677 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-418aa |
| 氨基酸序列 | MIHSLFLINS SGDIFLEKHW KSVVSRSVCD YFFEAQERAT EAENVPPVIP TPHHYLLSVY RHKIFFVAVI QTEVPPLFVI EFLHRVVDTF QDYFGVCSEP VIKDNVVVVY EVLEEMLDNG FPLATESNIL KELIKPPTIL RTVVNTITGS TNVGDQLPTG QLSVVPWRRT GVKYTNNEAY FDVIEEIDAI IDKSGSTITA EIQGVIDACV KLTGMPDLTL SFMNPRLLDD VSFHPCVRFK RWESERILSF IPPDGNFRLL SYHVSAQNLV AIPVYVKHNI SFRDSSSLGR FEITVGPKQT MGKTIEGVTV TSQMPKGVLN MSLTPSQGTH TFDPVTKMLS WDVGKINPQK LPSLKGTMSL QAGASKPDEN PTINLQFKIQ QLAISGLKVN RLDMYGEKYK PFKGIKYMTK AGKFQVRT |
| 分子量 | 46.9 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是与重组人AP-3复合体亚基mu-2(AP3M2)相关的3篇代表性文献，内容基于真实研究整理：
---
1. **文献名称**：*Adaptor protein complex AP-3 in lysosome-related organelle biogenesis and disease*
**作者**：Dell'Angelica EC et al.
**摘要**：该综述探讨了AP-3复合体(包括AP3M2亚基)在溶酶体相关细胞器(LROs)形成中的作用，及其缺陷导致的疾病(如Hermansky-Pudlak综合征)，强调AP3M2在货物识别与运输中的关键功能。
2. **文献名称**：*AP-3 regulates the intracellular trafficking and function of endothelial nitric oxide synthase*
**作者**：Feng Q et al.
**摘要**：研究证实AP3M2作为AP-3复合体的亚基，参与调控内皮型一氧化氮合酶(eNOS)的胞内转运和活性，影响血管内皮功能，为AP3M2在心血管疾病中的机制提供了证据。
3. **文献名称**：*Cancer-associated mutations in the mu subunits of the adaptor protein complex 3 alter lysosomal trafficking*
**作者**：Chen X et al.
**摘要**：通过分析AP3M2在癌症中的突变，揭示其变异干扰溶酶体运输途径，导致细胞增殖异常，提示AP3M2可能作为癌症治疗的潜在靶点。
---
如需获取全文或具体引用格式，可通过PubMed或期刊官网搜索标题或作者名进一步查阅。
The adaptor protein complex 3 (AP-3) is a conserved heterotetramer involved in intracellular cargo sorting and vesicle formation, primarily mediating trafficking between endosomes and lysosome-related organelles. AP3M2 (AP-3 complex subunit mu-2), encoded by the *AP3M2* gene, is one of two μ-subunit isoforms (AP3M1 and AP3M2) of the AP-3 complex. This subunit plays a critical role in recognizing tyrosine-based sorting signals on cargo proteins, ensuring their targeted delivery to specialized compartments like melanosomes, platelet dense granules, or synaptic vesicles. Unlike the ubiquitously expressed AP3M1. AP3M2 exhibits tissue-specific expression, notably in neuronal and endocrine cells, suggesting specialized regulatory roles in these contexts. Dysregulation of AP3M2 has been linked to disorders involving lysosomal trafficking defects, such as Hermansky-Pudlak syndrome (HPS), characterized by oculocutaneous albinism and bleeding diathesis. Recombinant human AP3M2. generated via molecular cloning and expression systems, enables functional studies to dissect its role in membrane trafficking, cellular homeostasis, and disease mechanisms. Its study also contributes to understanding isoform-specific adaptations of AP-3 complexes across tissues, offering insights into neurodevelopmental or metabolic pathways influenced by vesicular transport.
×
