| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ARID3C |
| Uniprot No | A6NKF2 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-412aa |
| 氨基酸序列 | MEALQKQQAARLAQGVGPLAPACPLLPPQPPLPDHRTLQAPEGALGNVGAEEEEDAEEDEEKREEAGAEEEAAEESRPGAQGPSSPSSQPPGLHPHEWTYEEQFKQLYELDADPKRKEFLDDLFSFMQKRGTPVNRVPIMAKQVLDLYALFRLVTAKGGLVEVINRKVWREVTRGLSLPTTITSAAFTLRTQYMKYLYPYECETRALSSPGELQAAIDSNRREGRRQAYTATPLFGLAGPPPRGAQDPALGPGPAPPATQSSPGPAQGSTSGLPAHACAQLSPSPIKKEESGIPNPCLALPVGLALGPTREKLAPEEPPEKRAVLMGPMDPPRPCMPPSFLPRGKVPLREERLDGPLNLAGSGISSINMALEINGVVYTGVLFARRQPVPASQGPTNPAPPPSTGPPSSILP |
| 分子量 | 71.72 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于ARID3C的3篇代表性文献摘要(基于近年研究主题模拟，供参考)：
1. **文献名称**：*ARID3C promotes tumor progression by regulating cell cycle in triple-negative breast cancer*
**作者**：Li Y, et al.
**摘要**：该研究揭示了ARID3C在三阴性乳腺癌中通过调控细胞周期相关基因(如CDK4、Cyclin D1)表达，促进肿瘤细胞增殖与转移的机制。
2. **文献名称**：*ARID3C interacts with SIN3A to modulate epigenetic silencing in colorectal cancer*
**作者**：Wang X, et al.
**摘要**：研究发现ARID3C可与转录抑制复合物SIN3A结合，通过介导组蛋白去乙酰化抑制抑癌基因表达，从而驱动结直肠癌进展。
3. **文献名称**：*Structural analysis of ARID3C reveals conserved DNA-binding motifs in the ARID family*
**作者**：Thompson JR, et al.
**摘要**：通过X射线晶体学解析了ARID3C的DNA结合结构域，发现其保守的AT-rich序列识别基序，为理解其染色质调控功能提供结构基础。
*注：以上文献及作者为示例性模拟，实际研究请通过PubMed或Google Scholar以“ARID3C”为关键词检索最新论文。*
ARID3C (AT-rich interaction domain protein 3C), a member of the ARID family of DNA-binding proteins, is involved in transcriptional regulation and chromatin remodeling. This protein family shares a conserved ARID domain (~100 amino acids) that recognizes AT-rich DNA sequences to mediate gene expression control and epigenetic modifications. Unlike its well-studied paralogs ARID3A and ARID3B, ARID3C remains poorly characterized, though its expression has been implicated in developmental processes and carcinogenesis. Structurally, recombinant ARID3C typically presents as a ~60 kDa nuclear protein, functioning through interactions with chromatin-modifying complexes and transcription factors.
Emerging studies suggest ARID3C participates in cell differentiation, proliferation, and tumor progression. It shows tissue-specific expression patterns, with elevated levels observed in certain cancers like neuroblastoma and hepatocellular carcinoma, potentially influencing oncogenic pathways. However, its exact molecular mechanisms and regulatory networks remain unclear. Recombinant ARID3C has been utilized experimentally to investigate DNA-binding properties and protein-protein interactions, aiding in deciphering its role in gene regulation. Current research focuses on validating its potential as a biomarker or therapeutic target, though functional insights remain preliminary compared to other ARID family members. Further characterization is needed to clarify its biological significance and disease associations.
×
