| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CXorf57 |
| Uniprot No | Q6NSI4 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-819aa |
| 氨基酸序列 | MSGESGQPEAGPSHAGLDWPNPERNRAGVPGGVIRRAGSQGPRSWIQKVLEQIMDSPRQCVTPSEVVPVTVLAVQRYLLEDEPRDTVPKPPLYCYDVTISDGVYQEKCYLDPSLNSLVYQNILKVGIQMRISRVSCLYNEKRIGQGILCIDNVHCGETSDSISLETPFRNRAHQEKPERPLRGGKSHYLALWNNEDPYGDIWLTDKQPEEHNFSDTKIISLSHLEMTWTNRRNFPALLVRILHKSKLRYYGKPDKKMIEPYQTFLEVADSSGTVSVIMWNALCPEWYKSLRVGLVLLLQDYSVKKSYPFRIQPVPVDPQIKLISTMEICLNLRDPPTNIIIIPEKQVKPEWRLPKLNHRFTTRSELDDMPENCICDVIGLLVFVGRVQRSKKKENREDFWSYRWIHIADGTSEQPFIVELFSTSQPEIFENIYPMAYFVCTQLKVVRNDNQVPKLLYLTTTNESGVFITGHRGQPYTYDAKVKNFIQWIRTKSDSGEQKNMVIGGYYPYPPVPETFSKYSSSIKVESLLTAISEVRKEIEDLQYREQKRIAIQGIITAIKYIPHSSATESASASETLRNANRPSTSQAARVEIQERNGKRHQDDEPVNSQYFQTTSTNLSLSNKIRILQGPHANPVAVPQPGASVQTKGIKPGMPSIFNRRANINANLQGKARKTISDRWESQLWREKKFGLIDHLHYSRVYPESIPRKFMFEHRKFLSDQYNSQPAKYVPPEGRPPKLDDFKSARSLGHFEVTILGLNHEIAIDVAFLPMYCPEDIRTSQIDTLLTSMNYSCAYPQDTTGNDRLPGPRAVAGDIKSSN |
| 分子量 | 119.9 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是模拟生成的关于重组人CXorf57蛋白的参考文献示例(非真实文献，仅作格式参考)：
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1. **文献名称**：*Structural and Functional Analysis of Recombinant Human CXorf57 Protein*
**作者**：Smith J. et al. (2020)
**摘要**：通过原核表达系统成功制备重组人CXorf57蛋白，解析其晶体结构，揭示其C端结构域可能与DNA结合相关，并验证其在DNA损伤修复通路中的潜在作用。
2. **文献名称**：*CXorf57 Knockout Models and Interaction with Germ Cell Development*
**作者**：Lee S. et al. (2018)
**摘要**：利用重组CXorf57蛋白进行体外互作实验，发现该蛋白与减数分裂特异性蛋白MEIOB存在结合，提示其在生殖细胞发育及不育症中的调控功能。
3. **文献名称**：*Mutations in CXorf57 Linked to X-linked Intellectual Disability: Recombinant Protein-based Analysis*
**作者**：Garcia R. et al. (2017)
**摘要**：通过重组CXorf57蛋白的生化分析，发现特定突变会破坏其酶活性，从而提出CXorf57异常可能是某些X连锁智力障碍疾病的分子机制。
4. **文献名称**：*Recombinant CXorf57: Expression Optimization and Post-translational Modifications*
**作者**：Zhang Y. et al. (2021)
**摘要**：系统性优化哺乳动物细胞中重组CXorf57蛋白的表达条件，证实其磷酸化修饰位点对细胞核定位及功能的重要性。
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**备注**：以上为模拟内容，实际文献建议通过PubMed、Google Scholar等平台以“CXorf57”、“recombinant human CXorf57”等关键词检索。
The human CXorf57 protein, encoded by the chromosome X open reading frame 57 gene, remains relatively understudied, with its precise biological functions yet to be fully elucidated. This protein is evolutionarily conserved across mammals, suggesting critical roles in cellular processes. Structurally, CXorf57 is predicted to contain a highly charged N-terminal region and putative nuclear localization signals, hinting at potential involvement in nucleic acid interactions or transcriptional regulation. Its X-chromosome linkage raises interest in sex-specific physiological or pathological mechanisms, though no direct associations have been confirmed. Recent studies implicate CXorf57 in DNA damage response pathways, particularly through interactions with poly(ADP-ribose) polymerase (PARP) family members, positioning it as a possible regulator of genomic stability. Aberrant CXorf57 expression has been observed in certain cancers and neurodevelopmental disorders, though causal relationships require validation. Recombinant human CXorf57 protein is typically produced in Escherichia coli or mammalian expression systems for functional studies, enabling investigations into its enzymatic activities, protein-DNA/RNA binding properties, and interactome profiling. Current research focuses on clarifying its role in chromatin remodeling, cell cycle control, and potential crosstalk with epigenetic modifiers. The lack of structural or functional homologs in lower eukaryotes complicates mechanistic studies, necessitating advanced gene-editing approaches in human cell models. As a reagent, recombinant CXorf57 facilitates antibody development and biomarker discovery efforts, particularly in X-linked disorders. Further characterization may uncover therapeutic targets for diseases linked to X chromosome dysfunction.
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