| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | DSCR5 |
| Uniprot No | P57054 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-134aa |
| 氨基酸序列 | MVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLTYWPQKYWAVALPVYLLIAIVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQQKKYQEEAIPALRDISISEVNQMFFLAAKELYTKN |
| 分子量 | 40.37 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇关于重组人DSCR5蛋白的模拟参考文献(注：文献为虚构示例，仅供格式参考)：
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1. **文献名称**：**"Expression and Functional Analysis of Recombinant Human DSCR5 in Down Syndrome-Related Pathways"**
**作者**：Li, X.; Wang, Y.; Zhang, R.
**摘要**：研究利用大肠杆菌系统成功表达并纯化重组人DSCR5蛋白，通过体外实验证明DSCR5可通过调控钙调神经磷酸酶(calcineurin)活性影响神经元分化，提示其在唐氏综合征神经发育异常中的潜在作用。
2. **文献名称**：**"DSCR5 as a Novel Angiogenic Regulator: Insights from Recombinant Protein-Based Assays"**
**作者**：García-Sánchez, A.; Fernández, M.
**摘要**：通过重组DSCR5蛋白处理内皮细胞，发现其显著促进血管生成相关基因(如VEGF、HIF-1α)的表达，首次揭示DSCR5在病理性血管增生中的调控功能。
3. **文献名称**：**"Structural and Biochemical Characterization of the DSCR5 Protein Complex in Down Syndrome"**
**作者**：Kim, J.; Park, S.; Lee, H.
**摘要**：利用重组DSCR5蛋白进行互作组学研究，鉴定出与DSCR5结合的多个神经元特异性蛋白，并通过冷冻电镜解析了其复合物结构，为唐氏综合征的分子机制提供了新视角。
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**注**：以上文献为模拟内容，实际研究中建议通过权威数据库(如PubMed、Web of Science)以“DSCR5”、“recombinant DSCR5”、“Down Syndrome Critical Region 5”等关键词检索最新文献。
**Background of Recombinant Human DSCR5 Protein**
Down Syndrome Critical Region 5 (DSCR5), also known as MCG10 or RCAN3. is a gene located within the Down syndrome critical region of human chromosome 21. It encodes a protein implicated in developmental regulation and cellular signaling, particularly in pathways involving calcineurin, a calcium-dependent phosphatase. DSCR5 is less characterized compared to its homolog RCAN1 (DSCR1), but studies suggest roles in stress response, neuronal development, and angiogenesis. Dysregulation of DSCR5 has been tentatively linked to Down syndrome-related pathologies and other conditions, such as cancer and cardiovascular diseases.
Recombinant human DSCR5 protein is engineered via molecular cloning, typically expressed in *E. coli* or mammalian systems to ensure proper folding and post-translational modifications. Its production enables functional studies, including interaction mapping with calcineurin or other signaling components, and exploration of its role in cellular proliferation and differentiation. Researchers also utilize recombinant DSCR5 to investigate its potential as a biomarker or therapeutic target. Despite progress, the exact molecular mechanisms and physiological relevance of DSCR5 remain understudied, necessitating further structural and functional analyses to clarify its contributions to health and disease.
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