Recombinant Human LILRA3 protein

中文名： 白细胞免疫球蛋白样受体亚家族A成员3(LILRA3)重组蛋白
别名： LILRA3；ILT6；LIR4；Leukocyte immunoglobulin-like receptor subfamily A member 3

货号: PA1000-7611

Price： ￥询价

20μg 50μg 100μg ＞100μg

数量：

大包装询价

产品详情

纯度	>95%SDS-PAGE.
种属	Human
靶点	LILRA3
Uniprot No	Q8N6C8
内毒素	< 0.01EU/μg
表达宿主	E.coli
表达区间	19-439aa
氨基酸序列	THVQAGPLPKPTLWAEPGSVITQGSPVTLRCQGSLETQEYHLYREKKTAL WITRIPQELVKKGQFPILSITWEHAGRYCCIYGSHTVGLSESSDPLELVV TGAYSKPTLSALPSPVVTSGGNVTIQCDSQVAFDGFILCKEGEDEHPQCL NSHSHARGSSRAIFSVGPVSPSRRWSYRCYGYDSRAPYVWSLPSDLLGLL VPGVSKKPSLSVQPGPVVAPGEKLTFQCGSDAGYDRFVLYKEWGRDFLQR PGRQPQAGLSQANFTLGPVSRSYGGQYTCSGAYNLSSEWSAPSDPLDILI TGQIRARPFLSVRPGPTVASGENVTLLCQSQGGMHTFLLTKEGAADSPLR LKSKRQSHKYQAEFPMSPVTSAHAGTYRCYGSLSSNPYLLTHPSDPLELV VSGAAETLSPPQNKSDSKAGEVDHHHHHH
预测分子量	47 kDa
蛋白标签	His tag N-Terminus
缓冲液	PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
稳定性 & 储存条件	Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶	Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

参考文献

以下是关于LILRA3重组蛋白的3篇代表性文献的简要信息(注：文献为模拟示例，实际需根据具体研究补充)：

1. **"Structural insights into LILRA3-mediated immune regulation"**

- **作者**: Smith A, et al.

- **摘要**: 通过X射线晶体学解析了重组LILRA3蛋白的胞外结构域三维结构，揭示了其与MHC-I类分子结合的特异性位点，为理解其在免疫抑制中的功能提供了分子基础。

2. **"LILRA3 modulates monocyte activation in autoimmune diseases"**

- **作者**: Zhang Y, et al.

- **摘要**: 研究重组LILRA3蛋白对单核细胞炎症因子分泌的影响，发现其通过抑制TLR信号通路减轻类风湿性关节炎模型中的炎症反应。

3. **"High-yield production of recombinant LILRA3 in mammalian cells"**

- **作者**: Lee H, et al.

- **摘要**: 开发了一种基于HEK293细胞的重组LILRA3蛋白高效表达和纯化系统，优化后的蛋白具有天然构象，适用于体外功能研究和药物开发。

如需具体文献，建议在PubMed或Web of Science中检索关键词“LILRA3 recombinant”或结合研究领域(如“LILRA3 structure/function”)。

背景信息

**Background of LILRA3 Recombinant Protein**

Leukocyte Immunoglobulin-Like Receptor A3 (LILRA3) is a soluble immunomodulatory protein belonging to the LILR family, which regulates immune responses by interacting with MHC class I molecules and other ligands. Located on chromosome 19q13.4. the *LILRA3* gene exhibits copy number variation and deletion polymorphisms in human populations, influencing its expression levels and disease susceptibility. Unlike other LILR family members, LILRA3 lacks transmembrane and cytoplasmic domains, existing primarily as a secreted protein. This unique structure enables it to modulate immune signaling pathways by competitively binding to shared ligands, thereby dampening receptor-mediated activation or inhibition in myeloid cells, lymphocytes, and other immune cells.

LILRA3 recombinant protein is engineered *in vitro* using expression systems (e.g., mammalian, insect, or bacterial cells) to produce purified, bioactive forms for research. It typically retains the extracellular immunoglobulin-like domains critical for ligand interaction. Studies link LILRA3 dysregulation to autoimmune diseases (e.g., rheumatoid arthritis, lupus), viral infections (e.g., HIV, hepatitis), and cancers, where it may serve as a biomarker or therapeutic target. For instance, reduced LILRA3 levels correlate with exacerbated inflammation in autoimmune conditions, while elevated expression in certain cancers may promote immune evasion.

Research on LILRA3 recombinant protein focuses on elucidating its precise mechanisms in immune homeostasis, pathogen defense, and tumor microenvironments. Its therapeutic potential includes blocking pro-inflammatory pathways or enhancing anti-tumor immunity. However, functional variability due to genetic polymorphisms necessitates careful characterization in diverse populations. Overall, LILRA3 recombinant protein is a vital tool for dissecting immune regulation and developing targeted therapies.