| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ERC1 |
| Uniprot No | Q8IUD2 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-91aa |
| 氨基酸序列 | MPKQVVWHGHWPAALSKQVAQIPPTWTFSSGAAPATLSHWVCDSPLHLSILHHFPSRKTDGRKPSVTLLLRRSISGTDIICLVSVNSKESS |
| 分子量 | 36.4 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下为基于学术研究背景模拟生成的关于重组人ERC1蛋白的参考文献示例(请注意文献为虚构示例，实际引用请核实真实数据库)：
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**1. 文献名称**：
*ERC1 Fusion Proteins in Ewing’s Sarcoma: Functional Characterization*
**作者**：T. Tsuji, M. Mao, et al.
**摘要**：
研究揭示了人ERC1蛋白与EWS基因的融合在尤文肉瘤中的致癌机制，发现重组ERC1蛋白的N端结构域通过激活MAPK通路促进肿瘤细胞增殖，为靶向治疗提供依据。
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**2. 文献名称**：
*Structural Insights into ERC1 Interaction with Rab6 GTPase*
**作者**：D. Bailly, H. Shimizu
**摘要**：
通过X射线晶体学解析了重组人ERC1蛋白与Rab6的结合界面，证实其C端卷曲螺旋结构域对细胞内囊泡运输的关键调控作用，阐明了ERC1在膜转运中的分子机制。
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**3. 文献名称**：
*ERC1 as a Novel DNA Damage Response Protein*
**作者**：P. Legros, S. Dupont
**摘要**：
发现重组ERC1蛋白在电离辐射后通过结合ATM激酶增强DNA修复活性，敲低实验显示其缺失导致细胞对辐射敏感，提示ERC1可能作为基因组稳定性调控因子。
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**注意事项**：
以上内容为模拟生成，实际文献请通过PubMed/Google Scholar检索关键词如 "ERC1 protein", "EWS-ERC1 fusion", "ERC1 Rab6 interaction" 获取。部分真实相关研究可能涉及 "EWSR1"(原称EWS)与ERC1的基因融合机制。
**Background of Recombinant Human ERC1 Protein**
The ERC1 (ELKS/Rab6-interacting/CAST family member 1) protein, also known as ELKS or CAST, is a multidomain scaffolding protein involved in diverse cellular processes. Structurally, ERC1 contains coiled-coil domains and interaction motifs that enable binding to partners like Rab6. RIM, and Piccolo, linking it to vesicle trafficking, cytoskeletal organization, and synaptic function. It plays a critical role in maintaining Golgi apparatus integrity, regulating exocytosis, and organizing active zones in neurons for neurotransmitter release.
Recombinant human ERC1 protein is engineered using expression systems (e.g., *E. coli* or mammalian cells*) to enable in vitro studies of its biochemical interactions and structural properties. Research highlights its involvement in cancer, where chromosomal translocations (e.g., *ERC1-RET* fusion in leukemia) drive oncogenesis, and in neurological disorders, as ERC1 interacts with synaptic proteins implicated in autism and schizophrenia. Its association with PKMζ in memory-related synaptic plasticity further underscores its neurobiological relevance.
By producing recombinant ERC1. scientists aim to dissect its role in intracellular signaling, screen therapeutic compounds targeting ERC1-associated pathways, and explore its diagnostic potential in diseases linked to ERC1 dysfunction.
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