| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | EXDL1 |
| Uniprot No | Q8NHP7 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-514aa |
| 氨基酸序列 | MEDSEFLAYVELLDEVEQGSVRAKASSVSLHAERTWMEKMKVEDLNVCEPASPAPEAPATSLLNDLKYSPSEEEEVTYTVINQFQQKFGAAILHIKKQNVLSVAAEGANVCRHGKLCWLQVATNCRVYLFDIFLLGSRAFHNGLQMILEDKRILKVIHDCRWLSDCLSHQYGILLNNVFDTQVADVLQFSMETGGYLPNCITTLQESLIKHLQVAPKYLSFLEKRQKLIQENPEVWFIRPVSPSLLKILALEATYLLPLRLALLDEMMSDLTTLVDGYLNTYREGSADRLGGTEPTCMELPEELLQLKDFQKQRREKAAREYRVNAQGLLIRTVLQPKKLVTETAGKEEKVKGFLFGKNFRIDKAPSFTSQDFHGDVNLLKEESLNKQATNPQHLPPTEEGETSEDSSNKLICTKSKGSEDQRITQKEHFMTPKHEFQASLSLKEETEQLLMVENKEDLKCTKQAVSMSSFPQETRVSPSDTFYPIRKTVVSTLPPCPALEKIDSWISPFLNLP |
| 分子量 | 84.7 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人EXDL1蛋白的3篇参考文献的简要信息(注：EXDL1蛋白的研究较为有限，以下内容基于公开文献的典型研究方向模拟概括，实际文献可能需要进一步核实)：
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1. **文献名称**：*Expression and Functional Characterization of Recombinant Human EXDL1 Protein in Escherichia coli*
**作者**：Li Y, Wang H, Chen J, et al.
**摘要内容**：本研究成功构建了重组人EXDL1蛋白的原核表达系统，通过大肠杆菌表达并纯化了高纯度蛋白。实验发现，EXDL1可能在细胞外基质的重塑中发挥作用，通过体外实验验证了其与特定胶原蛋白的相互作用。
2. **文献名称**：*EXDL1 Regulates Angiogenesis via Modulating VEGF Signaling in Endothelial Cells*
**作者**：Zhang R, Liu X, Patel S, et al.
**摘要内容**：通过重组EXDL1蛋白的体外功能实验，发现其能够增强血管内皮生长因子(VEGF)信号通路，促进内皮细胞迁移和管腔形成，提示其在血管生成中的潜在治疗价值。
3. **文献名称**：*Structural Insights into the EXDL1 Protein: Implications for Its Role in Tumor Microenvironment*
**作者**：Gomez M, Kim T, Park S, et al.
**摘要内容**：本研究解析了重组人EXDL1蛋白的晶体结构，揭示了其含有一个独特的结构域可能与细胞外基质蛋白的结合相关。进一步的体外实验表明，EXDL1的高表达与肿瘤微环境中成纤维细胞的激活有关。
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**注**：以上文献为模拟示例，实际研究中可能需要查询具体数据库(如PubMed、Web of Science)以获取真实文献。若研究方向不明确，建议结合实验背景扩展关键词(如EXDL1的别名或功能)。
Recombinant human EXDL1 protein is a genetically engineered form of the EXDL1 (Exonuclease-3'-5' Domain-Like 1) protein, encoded by the EXDL1 gene in humans. This protein belongs to the exonuclease family and is characterized by a conserved 3'-5' exonuclease domain, suggesting potential roles in nucleic acid metabolism, such as DNA repair, replication, or RNA processing. Though its precise biological functions remain under investigation, EXDL1 is hypothesized to interact with proteins involved in genome maintenance and stress response pathways. Studies indicate its expression in various tissues, with elevated levels observed in proliferating cells, implicating potential roles in cell cycle regulation or cancer progression.
Recombinant EXDL1 is typically produced using expression systems like *E. coli* or mammalian cell cultures, enabling scalable purification for functional and structural studies. Researchers employ this protein to dissect its enzymatic activity, substrate specificity, and interactions with DNA/RNA or partner proteins (e.g., helicases or polymerases). Its recombinant form is also used in high-throughput assays to screen for inhibitors or modulators, particularly in cancer therapeutics. Despite progress, EXDL1's physiological relevance—such as its involvement in diseases like cancer or neurodegeneration—remains poorly defined, necessitating further exploration. The development of recombinant EXDL1 thus represents a critical tool for unraveling its molecular mechanisms and therapeutic potential.
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