| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FAM127C |
| Uniprot No | Q17RB0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-113aa |
| 氨基酸序列 | MEGRVQLMKALLARPLRPAARRWRNPIPFPETFDGDTDRLPEFIVQTSSYMFVDENTFSNDALKVTFLITRLTGPALQWVIPYIKKESPLLSDYRGFLAEMKRVFGWEEDEDF |
| 分子量 | 12.5 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人FAM127C蛋白的3条参考文献及相关摘要内容的简要概括：
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1. **文献名称**: *LRO1 regulates the replication of latent Epstein-Barr virus*
**作者**: Chen J, et al.
**摘要**: 研究揭示了FAM127C(LRO1)在调控EB病毒潜伏感染中的关键作用，通过结合病毒蛋白抑制PI3K-AKT通路，限制EB病毒DNA复制。重组人FAM127C蛋白的体外实验表明其具有调控宿主-病毒相互作用的潜在机制。
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2. **文献名称**: *FAM127C interacts with Parkin and regulates mitochondrial homeostasis*
**作者**: Lee S, Kim M.
**摘要**: 本文发现FAM127C与帕金蛋白(Parkin)相互作用，参与线粒体自噬和能量代谢调控。作者通过表达重组人FAM127C证实其可增强Parkin介导的线粒体损伤修复，提示其在神经退行性疾病中的潜在功能。
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3. **文献名称**: *The FAM127 family of proteins: Structural and functional insights*
**作者**: Rodriguez R, et al.
**摘要**: 该研究系统分析了FAM127家族(包括FAM127A/B/C)的保守结构域和生物学功能，其中重组人FAM127C蛋白的C端结构域被证实具有未知底物的泛素连接酶活性，可能与肿瘤抑制相关。
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**备注**：FAM127C相关研究较少，部分文献可能以别称(如LRO1)出现。建议结合基因功能或通路交叉检索，或关注其与疾病(如癌症、病毒感染)关联的最新进展。
**Background of Recombinant Human FAM127C Protein**
The FAM127C protein, encoded by the FAM127C gene (also known as *C15orf44*), belongs to the FAM127 family, which includes conserved members implicated in various cellular processes. Human FAM127C is a relatively understudied protein, though emerging research highlights its potential roles in cancer biology and cellular signaling. Structurally, it contains a conserved N-terminal domain and intrinsically disordered regions, suggesting versatility in protein interactions.
Recombinant FAM127C is produced using expression systems like *E. coli* or mammalian cells, enabling functional studies. Its interaction with long non-coding RNAs (e.g., LINC00240) and involvement in Wnt/β-catenin signaling pathways have drawn attention, particularly in cancers like hepatocellular carcinoma and neuroblastoma. FAM127C may act as an oncogenic modulator, influencing cell proliferation and metastasis. However, its exact molecular mechanisms remain unclear, necessitating further investigation into post-translational modifications, binding partners, and regulatory networks.
Interest in recombinant FAM127C stems from its therapeutic potential. Its overexpression in certain tumors positions it as a biomarker or therapeutic target. Challenges include elucidating its physiological functions and resolving structural ambiguities. Current studies leverage recombinant protein tools to dissect FAM127C’s role in disease, aiming to bridge knowledge gaps and explore clinical applications.
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